PP6R3_MOUSE - dbPTM
PP6R3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PP6R3_MOUSE
UniProt AC Q922D4
Protein Name Serine/threonine-protein phosphatase 6 regulatory subunit 3
Gene Name Ppp6r3
Organism Mus musculus (Mouse).
Sequence Length 844
Subcellular Localization Cytoplasm. Nucleus.
Protein Description Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance (By similarity)..
Protein Sequence MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVSQMNDRLGEDESLLMKLYSFLLNESPLNPLLASFFSKVLSILISRKPEQIVDFLKKKRDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQDVLNWLNEERIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQVQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQILLTLLETRRPTFEGHIEICPPGMSHSACSVNKSVLEAIRGRLGSFHELLLEPPKKSVMKTTWGILDPPVGNTRLNVIRLISSLLQTNTSSINGDLMELNSIGVILDMFFKYTWNNFLHTQVEICIALILASPFENAENGTITDQDSTGDNLLLKHLFQKCQLIERILEAWDTNEKKQAEGGRRHGYMGHLTRIANCIVHSTDKGPNSALVQQLIKDLPDEVRERWETFCTNSLGETNKRNTVDLAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNESGNIALFEACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQDLFESSSANTEDKMEVDLNEPPTWSANFDVPMETTHGAPLDSVGSDVWSTEEPMPTKETGWASFSEFTSSLSTKESLRSNSPVEMETSTESVDPLTPGAAALATQPEAPGSMAMEASSDGEEDAESTDKVTETVMNGGMKETLSLTVDAKTETAVFKSEEEKLSTSQDAACKDAEETPEPAEAKCTAPLTPSSSPEQRTDQPSMPSDPSVNGPV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
222PhosphorylationLCEIVRLSRDQMLQV
HHHHHHHCHHHCHHC		24.2123140645
315PhosphorylationAIRGRLGSFHELLLE
HHHHCCCCHHHHHCC		28.2027180971
327PhosphorylationLLEPPKKSVMKTTWG
HCCCCCCCCCEECCC		33.30-
486UbiquitinationALVQQLIKDLPDEVR
HHHHHHHHCCCHHHH		62.90-
512 (in isoform 3)Phosphorylation-21.3026643407
512PhosphorylationGETNKRNTVDLAFSD
CCCCCCCCEEEECCH		21.3023649490
517 (in isoform 3)Phosphorylation-8.1022324799
518 (in isoform 3)Phosphorylation-29.7822324799
518PhosphorylationNTVDLAFSDYQMQQM
CCEEEECCHHHHHHH		29.78-
523 (in isoform 3)Phosphorylation-17.8626824392
524 (in isoform 3)Phosphorylation-31.6020469934
525 (in isoform 3)Phosphorylation-2.2026824392
526PhosphorylationDYQMQQMTSNFIDQF
HHHHHHHHHHHHHHH		19.0426239621
527PhosphorylationYQMQQMTSNFIDQFG
HHHHHHHHHHHHHHC		25.1326239621
550PhosphorylationQDDIGNVSFDRVSDI
CCCCCCEEEEEEEEE		25.9828973931
588PhosphorylationQQFDDGGSDEEDIWE
HCCCCCCCCHHHHHH		47.5924925903
602PhosphorylationEEKHIAFTPESQRRS
HHHEEEECHHHHCCC		19.6823684622
605PhosphorylationHIAFTPESQRRSSSG
EEEECHHHHCCCCCC		30.1422817900
609PhosphorylationTPESQRRSSSGSTDS
CHHHHCCCCCCCCCC		30.9220469934
610PhosphorylationPESQRRSSSGSTDSE
HHHHCCCCCCCCCCC		36.5925195567
611PhosphorylationESQRRSSSGSTDSEE
HHHCCCCCCCCCCCC		37.7029899451
613PhosphorylationQRRSSSGSTDSEEST
HCCCCCCCCCCCCCC		30.8720469934
614PhosphorylationRRSSSGSTDSEESTD
CCCCCCCCCCCCCCC		47.2520469934
620PhosphorylationSTDSEESTDSEEEDG
CCCCCCCCCCCCCCC		46.9925195567
622PhosphorylationDSEESTDSEEEDGAK
CCCCCCCCCCCCCHH		47.1725195567
635PhosphorylationAKQDLFESSSANTED
HHHHHHHCCCCCCCC		23.4321743459
636PhosphorylationKQDLFESSSANTEDK
HHHHHHCCCCCCCCC		26.6921743459
637PhosphorylationQDLFESSSANTEDKM
HHHHHCCCCCCCCCE		34.5125521595
640PhosphorylationFESSSANTEDKMEVD
HHCCCCCCCCCEECC		45.3221743459
689PhosphorylationEPMPTKETGWASFSE
CCCCCCCCCCCCHHH		39.3129899451
693PhosphorylationTKETGWASFSEFTSS
CCCCCCCCHHHHHHC		23.8525266776
695PhosphorylationETGWASFSEFTSSLS
CCCCCCHHHHHHCCC		29.3423984901
698PhosphorylationWASFSEFTSSLSTKE
CCCHHHHHHCCCHHH		17.2223984901
699PhosphorylationASFSEFTSSLSTKES
CCHHHHHHCCCHHHH		34.3023984901
700PhosphorylationSFSEFTSSLSTKESL
CHHHHHHCCCHHHHH		24.2323984901
702PhosphorylationSEFTSSLSTKESLRS
HHHHHCCCHHHHHHC		39.1026745281
704UbiquitinationFTSSLSTKESLRSNS
HHHCCCHHHHHHCCC		41.76-
706PhosphorylationSSLSTKESLRSNSPV
HCCCHHHHHHCCCCC		30.5525338131
709PhosphorylationSTKESLRSNSPVEME
CHHHHHHCCCCCEEC		47.1323737553
711PhosphorylationKESLRSNSPVEMETS
HHHHHCCCCCEECCC		31.4123737553
717PhosphorylationNSPVEMETSTESVDP
CCCCEECCCCCCCCC		39.3723737553
718PhosphorylationSPVEMETSTESVDPL
CCCEECCCCCCCCCC		19.5123737553
719PhosphorylationPVEMETSTESVDPLT
CCEECCCCCCCCCCC		39.4323737553
721PhosphorylationEMETSTESVDPLTPG
EECCCCCCCCCCCCC		31.7323649490
726PhosphorylationTESVDPLTPGAAALA
CCCCCCCCCCHHHHH		25.6818846507
734PhosphorylationPGAAALATQPEAPGS
CCHHHHHCCCCCCCC		45.5723737553
741PhosphorylationTQPEAPGSMAMEASS
CCCCCCCCCEEECCC		11.4323737553
747PhosphorylationGSMAMEASSDGEEDA
CCCEEECCCCCCCCH		18.6918846507
748PhosphorylationSMAMEASSDGEEDAE
CCEEECCCCCCCCHH		57.6018846507
756PhosphorylationDGEEDAESTDKVTET
CCCCCHHHCCHHHHH		43.5623649490
757PhosphorylationGEEDAESTDKVTETV
CCCCHHHCCHHHHHH		31.2018846507
761PhosphorylationAESTDKVTETVMNGG
HHHCCHHHHHHHCCC		31.5122817900
763PhosphorylationSTDKVTETVMNGGMK
HCCHHHHHHHCCCCE		18.7122817900
774PhosphorylationGGMKETLSLTVDAKT
CCCEEEEEEEEECCC		29.4322817900
776PhosphorylationMKETLSLTVDAKTET
CEEEEEEEEECCCCE		16.9922817900
795PhosphorylationSEEEKLSTSQDAACK
CHHHHCCCCCCCCCC		40.6229899451
796PhosphorylationEEEKLSTSQDAACKD
HHHHCCCCCCCCCCC		23.7629899451
816PhosphorylationEPAEAKCTAPLTPSS
CCCCCCCCCCCCCCC		30.5128066266
820PhosphorylationAKCTAPLTPSSSPEQ
CCCCCCCCCCCCHHH		21.7721082442
822PhosphorylationCTAPLTPSSSPEQRT
CCCCCCCCCCHHHCC		37.9122942356
823PhosphorylationTAPLTPSSSPEQRTD
CCCCCCCCCHHHCCC		51.6325521595
824PhosphorylationAPLTPSSSPEQRTDQ
CCCCCCCCHHHCCCC		36.4725521595
852Phosphorylation---------------
---------------		24719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PP6R3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PP6R3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PP6R3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PP6R3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PP6R3_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis.";
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
J. Proteome Res. 7:3957-3967(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-820 AND SER-824, ANDMASS SPECTROMETRY.
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588, AND MASSSPECTROMETRY.
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588, AND MASSSPECTROMETRY.

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