PTN1_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTN1_CHICK
• UniProt AC: O13016
• Protein Name: Tyrosine-protein phosphatase non-receptor type 1
• Gene Name: PTPN1
• Organism: Gallus gallus (Chicken).
• Sequence Length: 434
• Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity)..
• Protein Sequence: MEIEKEFHRLDQAASWAAIYQDIRHEASDFPCKVAKHPRNKNRNRYRDVSPFDHSRIKLNQGDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSIKCAQYWPRKEEKEMFFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPEYGPVVVHCSAGIGRSGTFCLVDTCLLLMDKRKDPSSVDVKQVLLEMRKYRMGLIQTADQLRFSYLAVIEGAKFIMGDASVQEQWKELSNEDLDPPPEHTPPPPRPPKRTSEMHNGRMHEHAEFFPKHQVVEEEIRCSVSTAEETVSDGRVFSSVPLITDSTSQDTEIRRRTVGENLHVTAHKEESKSESVEEDDENMMTTWKPFLVNICMFTFLTAGAYLCYRVCFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	RNRYRDVSPFDHSRI CCCCCCCCCCCCCCC	24.92	-
66	Phosphorylation	LNQGDNDYINASLIK CCCCCCCCCCHHHEE	11.43	-
152	Phosphorylation	ISEDIKSYYTVRQLE EEHHHHHHEEEEEEH	9.73	-
153	Phosphorylation	SEDIKSYYTVRQLEL EHHHHHHEEEEEEHH	13.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
152	Y	Phosphorylation	Kinase	FER	P16591	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTN1_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTN1_CHICK !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN1_CHICK	PTPN1	physical	9600099

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.