TSPY1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSPY1_HUMAN
• UniProt AC: Q01534
• Protein Name: Testis-specific Y-encoded protein 1
• Gene Name: TSPY1
• Organism: Homo sapiens (Human).
• Sequence Length: 308
• Subcellular Localization: Cytoplasm . Nucleus . Predominantly cytoplasmic. Also found in nucleus.
• Protein Description: May be involved in sperm differentiation and proliferation..
• Protein Sequence: MRPEGSLTYRVPERLRQGFCGVGRAAQALVCASAKEGTAFRMEAVQEGAAGVESEQAALGEEAVLLLDDIMAEVEVVAEEEGLVERREEAQRAQQAVPGPGPMTPESAPEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSALITDEDEDMLSYMVSLEVGEEKHPVHLCKIMLFFRSNPYFQNKVITKEYLVNITEYRASHSTPIEWYPDYEVEAYRRRHHNSSLNFFNWFSDHNFAGSNKIAEILCKDLWRNPLQYYKRMKPPEEGTETSGDSQLLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Ubiquitination	ALVCASAKEGTAFRM HHHHHCCCCCCCEEH	54.93	-
136	Ubiquitination	AFSRQREKMERRRKP HHHHHHHHHHHHCCC	48.53	-
142	Ubiquitination	EKMERRRKPHLDRRG HHHHHHCCCCHHHHC	34.67	-
193	Ubiquitination	SLEVGEEKHPVHLCK EEECCCCCCHHHEEE	49.24	-
214	Ubiquitination	SNPYFQNKVITKEYL CCHHHCCCCCCHHHE	25.00	21906983
214 (in isoform 2)	Ubiquitination	-	25.00	21906983
214 (in isoform 1)	Ubiquitination	-	25.00	21906983
218 (in isoform 2)	Ubiquitination	-	32.98	21906983
218 (in isoform 1)	Ubiquitination	-	32.98	21906983
218	Ubiquitination	FQNKVITKEYLVNIT HCCCCCCHHHEEEHH	32.98	21906983
253	Phosphorylation	YRRRHHNSSLNFFNW HHHHHCCCCCCEEHH	31.67	-
271	Ubiquitination	HNFAGSNKIAEILCK CCCCCCHHHHHHHHH	45.02	21906983
271 (in isoform 1)	Ubiquitination	-	45.02	21906983
278	Ubiquitination	KIAEILCKDLWRNPL HHHHHHHHHHHCCHH	53.03	21906983
278 (in isoform 1)	Ubiquitination	-	53.03	21906983
289	Ubiquitination	RNPLQYYKRMKPPEE CCHHHHHHHCCCCCC	40.87	21906983
289 (in isoform 1)	Ubiquitination	-	40.87	21906983
292	Ubiquitination	LQYYKRMKPPEEGTE HHHHHHCCCCCCCCC	62.55	2190698
292 (in isoform 1)	Ubiquitination	-	62.55	21906983
300	Phosphorylation	PPEEGTETSGDSQLL CCCCCCCCCCCCCCC	37.54	16426576

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
300	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
300	T	Phosphorylation	Kinase	CK2-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSPY1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSPY1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H2A2C_HUMAN	HIST2H2AC	physical	16996029
H2B2E_HUMAN	HIST2H2BE	physical	16996029

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.