LPAR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LPAR3_HUMAN
• UniProt AC: Q9UBY5
• Protein Name: Lysophosphatidic acid receptor 3
• Gene Name: LPAR3
• Organism: Homo sapiens (Human).
• Sequence Length: 353
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins..
• Protein Sequence: MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	N-linked_Glycosylation	KHMDFFYNRSNTDTV CCCCCCCCCCCCCCC	35.43	UniProtKB CARBOHYD
118	Phosphorylation	SSLTASLTNLLVIAV HHHHHHHHHHHHHHH	22.71	-
172	N-linked_Glycosylation	LGWNCLCNISACSSL CCHHHHHCHHHHHCC	20.50	UniProtKB CARBOHYD
184	Phosphorylation	SSLAPIYSRSYLVFW HCCCCCCCCCHHHHH	18.57	24719451
206	Phosphorylation	FLIMVVVYLRIYVYV HHHHHHHHHHHHHHH	4.43	24719451
216	Ubiquitination	IYVYVKRKTNVLSPH HHHHHHHCCCCCCCC	38.44	-
217	Phosphorylation	YVYVKRKTNVLSPHT HHHHHHCCCCCCCCC	34.29	27732954
221	Phosphorylation	KRKTNVLSPHTSGSI HHCCCCCCCCCCCCC	15.45	27732954
224	Phosphorylation	TNVLSPHTSGSISRR CCCCCCCCCCCCCCC	37.86	27732954
225	Phosphorylation	NVLSPHTSGSISRRR CCCCCCCCCCCCCCC	27.75	27732954
227	Phosphorylation	LSPHTSGSISRRRTP CCCCCCCCCCCCCCH	19.70	27732954
229	Phosphorylation	PHTSGSISRRRTPMK CCCCCCCCCCCCHHH	22.79	27732954
286	Phosphorylation	LLLALLNSVVNPIIY HHHHHHHHHHCHHHH	27.67	25219547
293	Phosphorylation	SVVNPIIYSYKDEDM HHHCHHHHCCCCHHH	13.48	25219547
294	Phosphorylation	VVNPIIYSYKDEDMY HHCHHHHCCCCHHHH	18.46	25219547
295	Phosphorylation	VNPIIYSYKDEDMYG HCHHHHCCCCHHHHH	12.89	25219547
301	Phosphorylation	SYKDEDMYGTMKKMI CCCCHHHHHHCHHHH	23.05	-
309	S-palmitoylation	GTMKKMICCFSQENP HHCHHHHHHCCCCCC	1.39	-
321	Phosphorylation	ENPERRPSRIPSTVL CCCCCCCCCCCCCCC	40.82	29449344
325	Phosphorylation	RRPSRIPSTVLSRSD CCCCCCCCCCCCCCC	28.86	30624053
326	Phosphorylation	RPSRIPSTVLSRSDT CCCCCCCCCCCCCCC	21.80	26471730
329	Phosphorylation	RIPSTVLSRSDTGSQ CCCCCCCCCCCCCCH	25.96	23312004
331	Phosphorylation	PSTVLSRSDTGSQYI CCCCCCCCCCCCHHH	35.83	24719451
333	Phosphorylation	TVLSRSDTGSQYIED CCCCCCCCCCHHHHC	39.72	27732954
335	Phosphorylation	LSRSDTGSQYIEDSI CCCCCCCCHHHHCHH	23.15	27732954
341	Phosphorylation	GSQYIEDSISQGAVC CCHHHHCHHHCCCCC	16.02	27732954
343	Phosphorylation	QYIEDSISQGAVCNK HHHHCHHHCCCCCCC	26.89	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LPAR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LPAR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LPAR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.