dbPTM

PLPP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PLPP4_HUMAN
UniProt AC	Q5VZY2
Protein Name	Phospholipid phosphatase 4 {ECO:0000312\|HGNC:HGNC:23531}
Gene Name	PLPP4 {ECO:0000312\|HGNC:HGNC:23531}
Organism	Homo sapiens (Human).
Sequence Length	271
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description	Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol..
Protein Sequence	MRELAIEIGVRALLFGVFVFTEFLDPFQRVIQPEEIWLYKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIRRTDKTEIKEAFLAVSLALALNGVCTNTIKLIVGRPRPDFFYRCFPDGVMNSEMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTESGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYICYRQHYPPLANTACHKPYVSLRVPASLKKEERPTADSAPSLPLEGITEGPV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
195	Phosphorylation	CAMMIALSRMCDYKH HHHHHHHHHHCCCCH	24719451
238	Phosphorylation	NTACHKPYVSLRVPA CCCCCCCEEEEECCC	28176486
240	Phosphorylation	ACHKPYVSLRVPASL CCCCCEEEEECCCCC	28176486
254	Phosphorylation	LKKEERPTADSAPSL CCCCCCCCCCCCCCC	29514088
257	Phosphorylation	EERPTADSAPSLPLE CCCCCCCCCCCCCCC	29514088
260	Phosphorylation	PTADSAPSLPLEGIT CCCCCCCCCCCCCCC	29514088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PLPP4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PLPP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PLPP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PLPP4_HUMAN	PPAPDC1A	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PLPP4_HUMAN

Related Literatures of Post-Translational Modification