dbPTM

TMPS4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TMPS4_HUMAN
UniProt AC	Q9NRS4
Protein Name	Transmembrane protease serine 4
Gene Name	TMPRSS4
Organism	Homo sapiens (Human).
Sequence Length	437
Subcellular Localization	Membrane Single-pass type II membrane protein .
Protein Description	Probable protease. Seems to be capable of activating ENaC (By similarity)..
Protein Sequence	MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	DSDQPLNSLDVKPLR CCCCCCCCCCCCCCC	33.36	23090842
28	Phosphorylation	KPRIPMETFRKVGIP CCCCCHHHHHHHCHH	23.61	24719451
31 (in isoform 2)	Ubiquitination	-	40.39	-
130	N-linked_Glycosylation	WFSACFDNFTEALAE HHHHHHHCHHHHHHH	26.03	UniProtKB CARBOHYD
178	N-linked_Glycosylation	SQELRMRNSSGPCLS CHHHHHHCCCCCCCC	31.05	UniProtKB CARBOHYD
262	Phosphorylation	NWKVRAGSDKLGSFP CCEEECCCCCCCCCH	30.50	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TMPS4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TMPS4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TMPS4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLC7A_HUMAN	CLEC7A	physical	25416956
TMM79_HUMAN	TMEM79	physical	25416956
KASH5_HUMAN	CCDC155	physical	25416956
SYNE4_HUMAN	SYNE4	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TMPS4_HUMAN

Related Literatures of Post-Translational Modification