| UniProt ID | KCNK1_HUMAN | |
|---|---|---|
| UniProt AC | O00180 | |
| Protein Name | Potassium channel subfamily K member 1 | |
| Gene Name | KCNK1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 336 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Recycling endosome . Cell junction, synapse . Cytoplasmic vesicle . Perikaryon . Cell projection, dendrite . Cell projection . Apical cell membrane Multi-pass membrane protein . The heterodimer with KCN |
|
| Protein Description | Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. [PubMed: 15820677] | |
| Protein Sequence | MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEQQLEQFLGRVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHIIEHDQLSFSSITDQAAGMKEDQKQNEPFVATQSSACVDGPANH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MLQSLAGSSCV ----CCHHHCCCHHH | 19.07 | 28188228 | |
| 8 | Phosphorylation | MLQSLAGSSCVRLVE CCHHHCCCHHHHHHH | 18.24 | 28188228 | |
| 9 | Phosphorylation | LQSLAGSSCVRLVER CHHHCCCHHHHHHHH | 18.73 | 28188228 | |
| 10 | S-palmitoylation | QSLAGSSCVRLVERH HHHCCCHHHHHHHHH | 1.90 | 29575903 | |
| 95 | N-linked_Glycosylation | YGVSVLSNASGNWNW CCEEEEECCCCCCCC | 33.68 | 8978667 | |
| 95 | N-linked_Glycosylation | YGVSVLSNASGNWNW CCEEEEECCCCCCCC | 33.68 | 11053038 | |
| 157 | Phosphorylation | TAVVQRITVHVTRRP HHHHHHHCCEECCCC | 13.52 | - | |
| 274 | Sumoylation | FCELHELKKFRKMFY HHHHHHHHHHHHCEE | 47.05 | - | |
| 274 | Sumoylation | FCELHELKKFRKMFY HHHHHHHHHHHHCEE | 47.05 | 20498050 | |
| 300 | Phosphorylation | IIEHDQLSFSSITDQ EEECCCCCHHHHHHH | 19.90 | 30266825 | |
| 302 | Phosphorylation | EHDQLSFSSITDQAA ECCCCCHHHHHHHHC | 19.91 | 30266825 | |
| 303 | Phosphorylation | HDQLSFSSITDQAAG CCCCCHHHHHHHHCC | 27.74 | 30266825 | |
| 305 | Phosphorylation | QLSFSSITDQAAGMK CCCHHHHHHHHCCCC | 24.81 | 21955146 | |
| 316 | Ubiquitination | AGMKEDQKQNEPFVA CCCCCHHHCCCCCEE | 68.37 | 21906983 | |
| 326 | Phosphorylation | EPFVATQSSACVDGP CCCEECCCCCCCCCC | 18.62 | 21082442 | |
| 327 | Phosphorylation | PFVATQSSACVDGPA CCEECCCCCCCCCCC | 18.83 | 28555341 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KCNK1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCNK1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCNK1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KCNK1_HUMAN | KCNK1 | physical | 8978667 | |
| VPP3_HUMAN | TCIRG1 | physical | 21988832 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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