TSNA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSNA1_HUMAN
• UniProt AC: Q96NA8
• Protein Name: t-SNARE domain-containing protein 1
• Gene Name: TSNARE1
• Organism: Homo sapiens (Human).
• Sequence Length: 513
• Subcellular Localization: Membrane; Single-pass membrane protein.
• Protein Sequence: MSYGSIARGGGLGSRGPFGGPSRQGCQPLECARCWTEYGIRHFPCPSPESKLQNRCVGKDGEGDLGPAGTPIVPRARKRGPGVAPEGSRMPEPTSSPTIGPRKDSAAGPHGRMAGPSTTRAKKRKPNFCPQETEVLVSKVSKHHQLLFGTGLLKAEPTRRYRVWSRILQAVNALGYCRRDVVDLKHKWRDLRAVVRRKLGDLRKAAHGPSPGSGKPQALALTPVEQVVAKTFSCQALPSEGFSLEPPRATQVDPCNLQELFQEMSANVFRINSSVTSLERSLQSLGTPSDTQELRDSLHTAQQETNKTIAASASSVKQMAELLRSSCPQERLQQERPQLDRLKTQLSDAIQCYGVVQKKIAEKSRALLPMAQRGSKQSPQAPFAELADDEKVFNGSDNMWQGQEQALLPDITEEDLEAIRLREEAILQMESNLLDVNQIIKDLASMVSEQGEAVDSIEASLEAASSHAEAARQLLAGASRHQLQRHKIKCCFLSAGVTALLVIIIIIATSVRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Methylation	MSYGSIARGGGLGSR CCCCCCCCCCCCCCC	42.49	115388153
47	Phosphorylation	IRHFPCPSPESKLQN CCCCCCCCHHHHHCC	48.28	28450419
88	Phosphorylation	PGVAPEGSRMPEPTS CCCCCCCCCCCCCCC	24.60	-
94	Phosphorylation	GSRMPEPTSSPTIGP CCCCCCCCCCCCCCC	39.93	29255136
95	Phosphorylation	SRMPEPTSSPTIGPR CCCCCCCCCCCCCCC	45.06	29255136
96	Phosphorylation	RMPEPTSSPTIGPRK CCCCCCCCCCCCCCC	28.65	29255136
98	Phosphorylation	PEPTSSPTIGPRKDS CCCCCCCCCCCCCCC	40.28	29255136
117	Phosphorylation	HGRMAGPSTTRAKKR CCCCCCCCCCHHHHC	41.30	29083192
118	Phosphorylation	GRMAGPSTTRAKKRK CCCCCCCCCHHHHCC	24.35	24275569
119	Phosphorylation	RMAGPSTTRAKKRKP CCCCCCCCHHHHCCC	32.73	29083192
125	Acetylation	TTRAKKRKPNFCPQE CCHHHHCCCCCCCCC	53.87	20167786
231	Phosphorylation	VEQVVAKTFSCQALP HHHHHHHHCCCEECC	15.84	24719451
243	Phosphorylation	ALPSEGFSLEPPRAT ECCCCCCCCCCCCCC	42.55	24719451
317	Ubiquitination	AASASSVKQMAELLR HHCHHHHHHHHHHHH	35.98	-
317	Ubiquitination	AASASSVKQMAELLR HHCHHHHHHHHHHHH	35.98	-
375	Phosphorylation	LPMAQRGSKQSPQAP HHHHHCCCCCCCCCC	29.70	28450419
378	Phosphorylation	AQRGSKQSPQAPFAE HHCCCCCCCCCCHHH	23.79	26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSNA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSNA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSNA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDE1_HUMAN	NDE1	physical	26186194
SNP29_HUMAN	SNAP29	physical	26186194
APOD_HUMAN	APOD	physical	28514442
NDE1_HUMAN	NDE1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.