CLN6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLN6_HUMAN
• UniProt AC: Q9NWW5
• Protein Name: Ceroid-lipofuscinosis neuronal protein 6
• Gene Name: CLN6
• Organism: Homo sapiens (Human).
• Sequence Length: 311
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Endoplasmic reticulum .
• Protein Sequence: MEATRRRQHLGATGGPGAQLGASFLQARHGSVSADEAARTAPFHLDLWFYFTLQNWVLDFGRPIAMLVFPLEWFPLNKPSVGDYFHMAYNVITPFLLLKLIERSPRTLPRSITYVSIIIFIMGASIHLVGDSVNHRLLFSGYQHHLSVRENPIIKNLKPETLIDSFELLYYYDEYLGHCMWYIPFFLILFMYFSGCFTASKAESLIPGPALLLVAPSGLYYWYLVTEGQIFILFIFTFFAMLALVLHQKRKRLFLDSNGLFLFSSFALTLLLVALWVAWLWNDPVLRKKYPGVIYVPEPWAFYTLHVSSRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEATRRRQHLG ----CCCHHHHHHCC	16.05	26074081
13	Phosphorylation	RRQHLGATGGPGAQL HHHHCCCCCCCCHHH	40.65	26074081
23	Phosphorylation	PGAQLGASFLQARHG CCHHHHHHHHHHHCC	25.37	23401153
31	Phosphorylation	FLQARHGSVSADEAA HHHHHCCCCCHHHHH	13.53	29255136
33	Phosphorylation	QARHGSVSADEAART HHHCCCCCHHHHHHH	31.53	23927012
63 (in isoform 2)	Phosphorylation	-	21.04	22496350
104	Phosphorylation	LLKLIERSPRTLPRS HHHHHHHCCCCCCCC	13.12	24719451
140	Phosphorylation	VNHRLLFSGYQHHLS CCHHHHHCCCCCCCC	36.24	23312004
142	Phosphorylation	HRLLFSGYQHHLSVR HHHHHCCCCCCCCCC	11.95	23312004
147	Phosphorylation	SGYQHHLSVRENPII CCCCCCCCCCCCCHH	18.12	23312004
290	Phosphorylation	DPVLRKKYPGVIYVP CHHHHHHCCCEEEEC	14.30	26552605
295	Phosphorylation	KKYPGVIYVPEPWAF HHCCCEEEECCCCEE	13.93	26552605
303	Phosphorylation	VPEPWAFYTLHVSSR ECCCCEEEEEECCCC	10.72	26552605
304	Phosphorylation	PEPWAFYTLHVSSRH CCCCEEEEEECCCCC	12.16	26552605
308	Phosphorylation	AFYTLHVSSRH---- EEEEEECCCCC----	15.77	26552605
309	Phosphorylation	FYTLHVSSRH----- EEEEECCCCC-----	33.03	26552605

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLN6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLN6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLN6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_HUMAN	VCP	physical	18811591

Drug and Disease Associations

• Kegg Disease
• H00149: Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuo
• H00810: Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (
• OMIM Disease
• 601780: Ceroid lipofuscinosis, neuronal, 6 (CLN6)
• 204300: Ceroid lipofuscinosis, neuronal, 4A (CLN4A)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY.
PubMed: 18691976

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY.
PubMed: 17081983

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY.
PubMed: 19369195