ENTP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENTP3_HUMAN
• UniProt AC: O75355
• Protein Name: Ectonucleoside triphosphate diphosphohydrolase 3
• Gene Name: ENTPD3
• Organism: Homo sapiens (Human).
• Sequence Length: 529
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Has a threefold preference for the hydrolysis of ATP over ADP..
• Protein Sequence: MFTVLTRQPCEQAGLKALYRTPTIIALVVLLVSIVVLVSITVIQIHKQEVLPPGLKYGIVLDAGSSRTTVYVYQWPAEKENNTGVVSQTFKCSVKGSGISSYGNNPQDVPRAFEECMQKVKGQVPSHLHGSTPIHLGATAGMRLLRLQNETAANEVLESIQSYFKSQPFDFRGAQIISGQEEGVYGWITANYLMGNFLEKNLWHMWVHPHGVETTGALDLGGASTQISFVAGEKMDLNTSDIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAMLLQNSPTKNHLTNPCYPRDYSISFTMGHVFDSLCTVDQRPESYNPNDVITFEGTGDPSLCKEKVASIFDFKACHDQETCSFDGVYQPKIKGPFVAFAGFYYTASALNLSGSFSLDTFNSSTWNFCSQNWSQLPLLLPKFDEVYARSYCFSANYIYHLFVNGYKFTEETWPQIHFEKEVGNSSIAWSLGYMLSLTNQIPAESPLIRLPIEPPVFVGTLAFFTAAALLCLAFLAYLCSATRRKRHSEHAFDHAVDSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MFTVLTRQPCEQA --CCEEECCCCCHHH	23.95	24719451
19	Phosphorylation	QAGLKALYRTPTIIA HHCHHHHHCCHHHHH	19.80	25278378
21	Phosphorylation	GLKALYRTPTIIALV CHHHHHCCHHHHHHH	15.95	25278378
23	Phosphorylation	KALYRTPTIIALVVL HHHHCCHHHHHHHHH	25.14	25278378
33	Phosphorylation	ALVVLLVSIVVLVSI HHHHHHHHHHHHHHH	15.05	25278378
39	Phosphorylation	VSIVVLVSITVIQIH HHHHHHHHHHHHHHH	14.37	25278378
41	Phosphorylation	IVVLVSITVIQIHKQ HHHHHHHHHHHHHCC	12.21	25278378
81	N-linked_Glycosylation	QWPAEKENNTGVVSQ ECCCCCCCCCCEEEE	63.53	UniProtKB CARBOHYD
95	Acetylation	QTFKCSVKGSGISSY EEEEEEEECCCCCCC	30.94	30588503
149	N-linked_Glycosylation	MRLLRLQNETAANEV HHHHHHCCHHHHHHH	53.85	UniProtKB CARBOHYD
238	N-linked_Glycosylation	AGEKMDLNTSDIMQV ECCCCCCCHHHHHHH	33.02	UniProtKB CARBOHYD
262	Phosphorylation	YTHSFQCYGRNEAEK EECCCEEECCCHHHH	14.34	-
381	N-linked_Glycosylation	YYTASALNLSGSFSL EEEEHHHCCCCCEEE	31.70	UniProtKB CARBOHYD
392	N-linked_Glycosylation	SFSLDTFNSSTWNFC CEEECCCCCCCCCCC	36.82	UniProtKB CARBOHYD
402	N-linked_Glycosylation	TWNFCSQNWSQLPLL CCCCCCCCHHHCCCC	24.87	UniProtKB CARBOHYD
454	N-linked_Glycosylation	HFEKEVGNSSIAWSL EEEECCCCCHHHHHH	37.45	UniProtKB CARBOHYD
475	Phosphorylation	TNQIPAESPLIRLPI CCCCCCCCCCCCCCC	27.41	24719451
528	Phosphorylation	AFDHAVDSD------ HHHHCCCCC------	38.32	25307156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENTP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENTP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENTP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYNE4_HUMAN	SYNE4	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.