dbPTM

TMM74_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TMM74_HUMAN
UniProt AC	Q96NL1
Protein Name	Transmembrane protein 74
Gene Name	TMEM74
Organism	Homo sapiens (Human).
Sequence Length	305
Subcellular Localization	Lysosome membrane Multi-pass membrane protein . Cytoplasmic vesicle, autophagosome membrane Multi-pass membrane protein .
Protein Description	Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction..
Protein Sequence	MELHYLAKKSNQADLCDARDWSSRGLPGDQADTAATRAALCCQKQCASTPRATEMEGSKLSSSPASPSSSLQNSTLQPDAFPPGLLHSGNNQITAERKVCNCCSQELETSFTYVDKNINLEQRNRSSPSAKGHNHPGELGWENPNEWSQEAAISLISEEEDDTSSEATSSGKSIDYGFISAILFLVTGILLVIISYIVPREVTVDPNTVAAREMERLEKESARLGAHLDRCVIAGLCLLTLGGVILSCLLMMSMWKGELYRRNRFASSKESAKLYGSFNFRMKTSTNENTLELSLVEEDALAVQS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	LCDARDWSSRGLPGD CCCCCCHHHCCCCCC	17.91	22468782
33	Phosphorylation	LPGDQADTAATRAAL CCCCHHHHHHHHHHH	22.62	22468782
36	Phosphorylation	DQADTAATRAALCCQ CHHHHHHHHHHHHHH	20.55	22468782
275	Phosphorylation	SKESAKLYGSFNFRM CHHHHHHHCEEEEEE	15.26	29978859
277	Phosphorylation	ESAKLYGSFNFRMKT HHHHHHCEEEEEEEC	11.94	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TMM74_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TMM74_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TMM74_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TMM74_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TMM74_HUMAN

Related Literatures of Post-Translational Modification