H4G_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H4G_HUMAN
• UniProt AC: Q99525
• Protein Name: Histone H4-like protein type G
• Gene Name: HIST1H4G
• Organism: Homo sapiens (Human).
• Sequence Length: 98
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity)..
• Protein Sequence: MSVRGKAGKGLGKGGAKCHRKVLSDNIQGITKCTIRRLARHGGVKRILGLIYEETRRVFKVFLENVIWYAVTNTEHAKRKTVTAMAVVYVLKRQGRTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MSVRGKAGKGLGK --CCCCCCCCCCCCC	43.32	16916647
9	Acetylation	SVRGKAGKGLGKGGA CCCCCCCCCCCCCHH	56.68	16916647
13	Acetylation	KAGKGLGKGGAKCHR CCCCCCCCCHHHHHH	60.25	16916647
13	Ubiquitination	KAGKGLGKGGAKCHR CCCCCCCCCHHHHHH	60.25	33845483
17	Acetylation	GLGKGGAKCHRKVLS CCCCCHHHHHHHHHH	33.57	25953088
24	Phosphorylation	KCHRKVLSDNIQGIT HHHHHHHHCCCCCHH	31.44	23898821
31	Phosphorylation	SDNIQGITKCTIRRL HCCCCCHHHHHHHHH	27.22	20164059
52	Phosphorylation	KRILGLIYEETRRVF HHHHHHHHHHHHHHH	16.86	-
78	Ubiquitination	VTNTEHAKRKTVTAM HHCCHHHCHHHHHHH	57.23	22817900
80	Ubiquitination	NTEHAKRKTVTAMAV CCHHHCHHHHHHHHH	46.79	22817900
89	Phosphorylation	VTAMAVVYVLKRQGR HHHHHHHHHHHHCCC	8.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H4G_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H4G_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H4G_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATRAP_HUMAN	AGTRAP	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.