CO8A2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO8A2_HUMAN
• UniProt AC: P25067
• Protein Name: Collagen alpha-2(VIII) chain
• Gene Name: COL8A2
• Organism: Homo sapiens (Human).
• Sequence Length: 703
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane.
• Protein Description: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity)..
• Protein Sequence: MLGTLTPLSSLLLLLLVLVLGCGPRASSGGGAGGAAGYAPVKYIQPMQKGPVGPPFREGKGQYLEMPLPLLPMDLKGEPGPPGKPGPRGPPGPPGFPGKPGMGKPGLHGQPGPAGPPGFSRMGKAGPPGLPGKVGPPGQPGLRGEPGIRGDQGLRGPPGPPGLPGPSGITIPGKPGAQGVPGPPGFQGEPGPQGEPGPPGDRGLKGDNGVGQPGLPGAPGQGGAPGPPGLPGPAGLGKPGLDGLPGAPGDKGESGPPGVPGPRGEPGAVGPKGPPGVDGVGVPGAAGLPGPQGPSGAKGEPGTRGPPGLIGPTGYGMPGLPGPKGDRGPAGVPGLLGDRGEPGEDGEPGEQGPQGLGGPPGLPGSAGLPGRRGPPGPKGEAGPGGPPGVPGIRGDQGPSGLAGKPGVPGERGLPGAHGPPGPTGPKGEPGFTGRPGGPGVAGALGQKGDLGLPGQPGLRGPSGIPGLQGPAGPIGPQGLPGLKGEPGLPGPPGEGRAGEPGTAGPTGPPGVPGSPGITGPPGPPGPPGPPGAPGAFDETGIAGLHLPNGGVEGAVLGKGGKPQFGLGELSAHATPAFTAVLTSPFPASGMPVKFDRTLYNGHSGYNPATGIFTCPVGGVYYFAYHVHVKGTNVWVALYKNNVPATYTYDEYKKGYLDQASGGAVLQLRPNDQVWVQMPSDQANGLYSTEYIHSSFSGFLLCPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
254	Phosphorylation	APGDKGESGPPGVPG CCCCCCCCCCCCCCC	66.33	30257219
578	Phosphorylation	AHATPAFTAVLTSPF CCCCCCEEEEECCCC	20.26	22210691
588	Phosphorylation	LTSPFPASGMPVKFD ECCCCCCCCCCCEEE	35.54	22210691
648	Phosphorylation	NVPATYTYDEYKKGY CCCCEEEHHHHHCCC	9.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO8A2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO8A2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO8A2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SGTA_HUMAN	SGTA	physical	25416956
CRTAP_HUMAN	CRTAP	physical	26186194
COL12_HUMAN	COLEC12	physical	26186194
CO2A1_HUMAN	COL2A1	physical	26186194
GT252_HUMAN	COLGALT2	physical	26186194
COEA1_HUMAN	COL14A1	physical	26186194
P3H1_HUMAN	P3H1	physical	26186194
FINC_HUMAN	FN1	physical	26186194
P4HA2_HUMAN	P4HA2	physical	26186194
CO5A1_HUMAN	COL5A1	physical	26186194
FKB14_HUMAN	FKBP14	physical	26186194
CO4A2_HUMAN	COL4A2	physical	26186194
COIA1_HUMAN	COL18A1	physical	26186194
CO5A1_HUMAN	COL5A1	physical	28514442
CO2A1_HUMAN	COL2A1	physical	28514442
COEA1_HUMAN	COL14A1	physical	28514442
FINC_HUMAN	FN1	physical	28514442
CO4A5_HUMAN	COL4A5	physical	28514442
COL12_HUMAN	COLEC12	physical	28514442
P4HA2_HUMAN	P4HA2	physical	28514442
CO4A2_HUMAN	COL4A2	physical	28514442
COIA1_HUMAN	COL18A1	physical	28514442
FKB14_HUMAN	FKBP14	physical	28514442
CO4A6_HUMAN	COL4A6	physical	28514442
GT252_HUMAN	COLGALT2	physical	28514442
CRTAP_HUMAN	CRTAP	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.