dbPTM

PAQR5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PAQR5_HUMAN
UniProt AC	Q9NXK6
Protein Name	Membrane progestin receptor gamma {ECO:0000303\|PubMed:23763432}
Gene Name	PAQR5 {ECO:0000312\|HGNC:HGNC:29645}
Organism	Homo sapiens (Human).
Sequence Length	330
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Plasma membrane progesterone (P4) receptor coupled to G proteins. [PubMed: 23763432 Seems to act through a G(i) mediated pathway]
Protein Sequence	MLSLKLPRLFSIDQIPQVFHEQGILFGYRHPQSSATACILSLFQMTNETLNIWTHLLPFWFFAWRFVTALYMTDIKNDSYSWPMLVYMCTSCVYPLVSSCAHTFSSMSKNARHICYFLDYGAVNLFSLGSAIAYSAYTFPDALMCTTFHDYYVALAVLNTILSTGLSCYSRFLEIQKPRLCKVIRVLAFAYPYTWDSLPIFYRLFLFPGESAQNEATSYHQKHMIMTLLASFLYSAHLPERLAPGRFDYIGHSHQLFHVCVILATHMQMEAILLDKTLRKEWLLATSKPFSFSQIAGAILLCIIFSLSNIIYFSAALYRIPKPELHKKET

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
3	Phosphorylation	-----MLSLKLPRLF -----CCCCCCCCCC	24719451
5	Ubiquitination	---MLSLKLPRLFSI ---CCCCCCCCCCCH	-
219	Phosphorylation	AQNEATSYHQKHMIM HHCCCCHHHHHHHHH	17053785
227	Phosphorylation	HQKHMIMTLLASFLY HHHHHHHHHHHHHHH	26546556

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PAQR5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PAQR5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PAQR5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYNE4_HUMAN	SYNE4	physical	25416956
PHYIP_HUMAN	PHYHIP	physical	26186194
PHYIP_HUMAN	PHYHIP	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PAQR5_HUMAN

Related Literatures of Post-Translational Modification