PHYIP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHYIP_HUMAN
• UniProt AC: Q92561
• Protein Name: Phytanoyl-CoA hydroxylase-interacting protein
• Gene Name: PHYHIP
• Organism: Homo sapiens (Human).
• Sequence Length: 330
• Protein Description: Its interaction with PHYH suggests a role in the development of the central system..
• Protein Sequence: MELLSTPHSIEINNITCDSFRISWAMEDSDLERVTHYFIDLNKKENKNSNKFKHRDVPTKLVAKAVPLPMTVRGHWFLSPRTEYSVAVQTAVKQSDGEYLVSGWSETVEFCTGDYAKEHLAQLQEKAEQIAGRMLRFSVFYRNHHKEYFQHARTHCGNMLQPYLKDNSGSHGSPTSGMLHGVFFSCNTEFNTGQPPQDSPYGRWRFQIPAQRLFNPSTNLYFADFYCMYTAYHYAILVLAPKGSLGDRFCRDRLPLLDIACNKFLTCSVEDGELVFRHAQDLILEIIYTEPVDLSLGTLGEISGHQLMSLSTADAKKDPSCKTCNISVGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	N-linked_Glycosylation	PHSIEINNITCDSFR CCEEEECCEEECEEE	36.29	UniProtKB CARBOHYD
44	Acetylation	YFIDLNKKENKNSNK EEEECCCCCCCCCCC	66.50	7683419
47	Acetylation	DLNKKENKNSNKFKH ECCCCCCCCCCCCCC	63.95	7683429
51	Acetylation	KENKNSNKFKHRDVP CCCCCCCCCCCCCCC	56.46	7683439
59	Phosphorylation	FKHRDVPTKLVAKAV CCCCCCCHHHHEEEE	36.54	-
64	Ubiquitination	VPTKLVAKAVPLPMT CCHHHHEEEECCCEE	42.30	30230243
71	Phosphorylation	KAVPLPMTVRGHWFL EEECCCEEEECEEEE	12.71	-
79	Phosphorylation	VRGHWFLSPRTEYSV EECEEEECCCCEEEE	11.67	20886841
126	Ubiquitination	HLAQLQEKAEQIAGR HHHHHHHHHHHHHHH	44.24	30230243
188	Phosphorylation	GVFFSCNTEFNTGQP EEEEECCCCCCCCCC	46.40	-
192	Phosphorylation	SCNTEFNTGQPPQDS ECCCCCCCCCCCCCC	42.38	-
325	N-linked_Glycosylation	DPSCKTCNISVGR-- CCCCCCCCCEECC--	34.50	UniProtKB CARBOHYD
327	Phosphorylation	SCKTCNISVGR---- CCCCCCCEECC----	12.43	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHYIP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHYIP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHYIP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDA11_HUMAN	HDAC11	physical	16169070
WDR89_HUMAN	WDR89	physical	16169070
MAGD4_HUMAN	MAGED4B	physical	16169070
F131A_HUMAN	FAM131A	physical	16169070
MET18_HUMAN	METTL18	physical	16169070
NDUV3_HUMAN	NDUFV3	physical	16169070
PPIE_HUMAN	PPIE	physical	16169070
S10AD_HUMAN	S100A13	physical	16169070
ANM5_HUMAN	PRMT5	physical	16169070
SMRC2_HUMAN	SMARCC2	physical	16169070
ZZEF1_HUMAN	ZZEF1	physical	16169070
ERG28_HUMAN	C14orf1	physical	16169070
CSN6_HUMAN	COPS6	physical	16169070
EF1A1_HUMAN	EEF1A1	physical	16169070
MED8_HUMAN	MED8	physical	16169070
NDRG1_HUMAN	NDRG1	physical	16169070
TTHY_HUMAN	TTR	physical	16169070
PLPL2_HUMAN	PNPLA2	physical	16169070
KIF15_HUMAN	KIF15	physical	26186194
PTH2_HUMAN	PTRH2	physical	26186194
KPCD2_HUMAN	PRKD2	physical	26186194
LIMD1_HUMAN	LIMD1	physical	26186194
TRIP6_HUMAN	TRIP6	physical	26186194
KIF15_HUMAN	KIF15	physical	28514442
LIMD1_HUMAN	LIMD1	physical	28514442
KPCD2_HUMAN	PRKD2	physical	28514442
TRIP6_HUMAN	TRIP6	physical	28514442
PTH2_HUMAN	PTRH2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.