RMD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RMD2_HUMAN
• UniProt AC: Q96LZ7
• Protein Name: Regulator of microtubule dynamics protein 2
• Gene Name: RMDN2
• Organism: Homo sapiens (Human).
• Sequence Length: 410
• Subcellular Localization: Membrane ; Single-pass membrane protein . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Als
• Protein Sequence: MPYSTNKELILGIMVGTAGISLLLLWYHKVRKPGIAMKLPEFLSLGNTFNSITLQDEIHDDQGTTVIFQERQLQILEKLNELLTNMEELKEEIRFLKEAIPKLEEYIQDELGGKITVHKISPQHRARKRRLPTIQSSATSNSSEEAESEGGYITANTDTEEQSFPVPKAFNTRVEELNLDVLLQKVDHLRMSESGKSESFELLRDHKEKFRDEIEFMWRFARAYGDMYELSTNTQEKKHYANIGKTLSERAINRAPMNGHCHLWYAVLCGYVSEFEGLQNKINYGHLFKEHLDIAIKLLPEEPFLYYLKGRYCYTVSKLSWIEKKMAATLFGKIPSSTVQEALHNFLKAEELCPGYSNPNYMYLAKCYTDLEENQNALKFCNLALLLPTVTKEDKEAQKEMQKIMTSLKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	ISLLLLWYHKVRKPG HHHHHHHHHHCCCCC	7.54	-
33 (in isoform 2)	Phosphorylation	-	28.94	-
36 (in isoform 2)	Phosphorylation	-	8.58	-
41 (in isoform 2)	Phosphorylation	-	70.43	-
44	Phosphorylation	MKLPEFLSLGNTFNS HCHHHHHHCCCCCCE	39.28	26503514
48	Phosphorylation	EFLSLGNTFNSITLQ HHHHCCCCCCEEEEC	23.54	26503514
51	Phosphorylation	SLGNTFNSITLQDEI HCCCCCCEEEECCEE	16.86	26503514
64	Phosphorylation	EIHDDQGTTVIFQER EEECCCCCEEEEEHH	16.56	26503514
90	Ubiquitination	LTNMEELKEEIRFLK HHCHHHHHHHHHHHH	57.49	-
116	Phosphorylation	DELGGKITVHKISPQ HHHCCCEEEEECCHH	21.75	23927012
121	Phosphorylation	KITVHKISPQHRARK CEEEEECCHHHHHHH	24.26	30266825
128 (in isoform 2)	Phosphorylation	-	40.67	25999147
129 (in isoform 2)	Phosphorylation	-	39.55	25999147
133	Phosphorylation	ARKRRLPTIQSSATS HHHCCCCHHHCCCCC	35.92	26471730
136	Phosphorylation	RRLPTIQSSATSNSS CCCCHHHCCCCCCCC	20.35	26471730
137	Phosphorylation	RLPTIQSSATSNSSE CCCHHHCCCCCCCCH	21.13	26471730
139	Phosphorylation	PTIQSSATSNSSEEA CHHHCCCCCCCCHHH	30.32	26471730
140	Phosphorylation	TIQSSATSNSSEEAE HHHCCCCCCCCHHHH	34.14	26471730
142	Phosphorylation	QSSATSNSSEEAESE HCCCCCCCCHHHHHC	38.60	29523821
143	Phosphorylation	SSATSNSSEEAESEG CCCCCCCCHHHHHCC	43.64	29523821
148	Phosphorylation	NSSEEAESEGGYITA CCCHHHHHCCCEEEC	48.89	29523821
149 (in isoform 2)	Phosphorylation	-	48.41	29978859
152	Phosphorylation	EAESEGGYITANTDT HHHHCCCEEECCCCC	13.12	29523821
154	Phosphorylation	ESEGGYITANTDTEE HHCCCEEECCCCCCC	12.84	29523821
157	Phosphorylation	GGYITANTDTEEQSF CCEEECCCCCCCCCC	41.66	14702039
159	Phosphorylation	YITANTDTEEQSFPV EEECCCCCCCCCCCC	39.11	22468782
163 (in isoform 2)	Phosphorylation	-	34.49	29978859
163	Phosphorylation	NTDTEEQSFPVPKAF CCCCCCCCCCCCCHH	34.49	24275569
185	Ubiquitination	NLDVLLQKVDHLRMS CHHHHHHHCCHHHCC	49.99	-
306	Phosphorylation	LPEEPFLYYLKGRYC CCCCCHHEEECCCEE	13.71	18083107
307	Phosphorylation	PEEPFLYYLKGRYCY CCCCHHEEECCCEEE	12.23	18083107
312	Phosphorylation	LYYLKGRYCYTVSKL HEEECCCEEEEEHHH	9.85	-
320	Phosphorylation	CYTVSKLSWIEKKMA EEEEHHHHHHHHHHH	29.73	27251275
329	Phosphorylation	IEKKMAATLFGKIPS HHHHHHHHHHCCCCC	17.06	27251275
406	Phosphorylation	KEMQKIMTSLKR--- HHHHHHHHHHCC---	34.09	-
409	Methylation	QKIMTSLKR------ HHHHHHHCC------	56.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RMD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RMD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RMD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RMD3_HUMAN	RMDN3	physical	26186194
VAPB_HUMAN	VAPB	physical	26186194
RMD3_HUMAN	RMDN3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.