dbPTM

TMM51_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TMM51_HUMAN
UniProt AC	Q9NW97
Protein Name	Transmembrane protein 51
Gene Name	TMEM51
Organism	Homo sapiens (Human).
Sequence Length	253
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MMAQSKANGSHYALTAIGLGMLVLGVIMAMWNLVPGFSAAEKPTAQGSNKTEVGGGILKSKTFSVAYVLVGAGVMLLLLSICLSIRDKRKQRQGEDLAHVQHPTGAGPHAQEEDSQEEEEEDEEAASRYYVPSYEEVMNTNYSEARGEEQNPRLSISLPSYESLTGLDETTPTSTRADVEASPGNPPDRQNSKLAKRLKPLKVRRIKSEKLHLKDFRINLPDKNVPPPSIEPLTPPPQYDEVQEKAPDTRPPD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	EKPTAQGSNKTEVGG HCCCCCCCCCCEECC	24.07	-
62	Phosphorylation	GGILKSKTFSVAYVL CCCCCCCCCCHHHHH	28.38	-
104	Phosphorylation	LAHVQHPTGAGPHAQ CCCCCCCCCCCCCCC	37.22	23927012
115	Phosphorylation	PHAQEEDSQEEEEED CCCCCCCCHHHHHHH	42.65	30266825
127	Phosphorylation	EEDEEAASRYYVPSY HHHHHHHHHHCCCCH	28.06	23927012
129	Phosphorylation	DEEAASRYYVPSYEE HHHHHHHHCCCCHHH	13.30	22817900
130	Phosphorylation	EEAASRYYVPSYEEV HHHHHHHCCCCHHHH	12.55	29449344
133	Phosphorylation	ASRYYVPSYEEVMNT HHHHCCCCHHHHHCC	34.82	25849741
134	Phosphorylation	SRYYVPSYEEVMNTN HHHCCCCHHHHHCCC	15.27	25849741
140	Phosphorylation	SYEEVMNTNYSEARG CHHHHHCCCHHHHCC	19.89	27642862
142	Phosphorylation	EEVMNTNYSEARGEE HHHHCCCHHHHCCCC	13.07	27259358
143	Phosphorylation	EVMNTNYSEARGEEQ HHHCCCHHHHCCCCC	27.18	29978859
155	Phosphorylation	EEQNPRLSISLPSYE CCCCCCEEEECCCHH	16.06	24300666
157	Phosphorylation	QNPRLSISLPSYESL CCCCEEEECCCHHHH	30.74	28387310
160	Phosphorylation	RLSISLPSYESLTGL CEEEECCCHHHHCCC	46.99	26657352
161	Phosphorylation	LSISLPSYESLTGLD EEEECCCHHHHCCCC	13.96	26657352
163	Phosphorylation	ISLPSYESLTGLDET EECCCHHHHCCCCCC	24.01	25137130
165	Phosphorylation	LPSYESLTGLDETTP CCCHHHHCCCCCCCC	45.00	27251275
170	Phosphorylation	SLTGLDETTPTSTRA HHCCCCCCCCCCCHH	37.43	24300666
171	Phosphorylation	LTGLDETTPTSTRAD HCCCCCCCCCCCHHH	23.63	24300666
173	Phosphorylation	GLDETTPTSTRADVE CCCCCCCCCCHHHHH	40.41	24300666
174	Phosphorylation	LDETTPTSTRADVEA CCCCCCCCCHHHHHC	19.66	24300666
175	Phosphorylation	DETTPTSTRADVEAS CCCCCCCCHHHHHCC	32.14	24300666
182	Phosphorylation	TRADVEASPGNPPDR CHHHHHCCCCCCCCH	21.60	19664994
192	Phosphorylation	NPPDRQNSKLAKRLK CCCCHHHCHHHHHHC	22.25	25159151
193	Ubiquitination	PPDRQNSKLAKRLKP CCCHHHCHHHHHHCC	61.07	-
202	Ubiquitination	AKRLKPLKVRRIKSE HHHHCCCEEEEECCC	42.07	-
208	Phosphorylation	LKVRRIKSEKLHLKD CEEEEECCCCCCCCC	37.28	28857561
210	Ubiquitination	VRRIKSEKLHLKDFR EEEECCCCCCCCCCE	48.58	-
214	Ubiquitination	KSEKLHLKDFRINLP CCCCCCCCCCEECCC	44.03	-
223	Ubiquitination	FRINLPDKNVPPPSI CEECCCCCCCCCCCC	58.88	-
229	Phosphorylation	DKNVPPPSIEPLTPP CCCCCCCCCCCCCCC	45.41	30206219
234	Phosphorylation	PPSIEPLTPPPQYDE CCCCCCCCCCCCCHH	44.45	23401153
239	Phosphorylation	PLTPPPQYDEVQEKA CCCCCCCCHHHHHHC	21.61	25884760
245	Ubiquitination	QYDEVQEKAPDTRPP CCHHHHHHCCCCCCC	48.40	-
249	Phosphorylation	VQEKAPDTRPPD--- HHHHCCCCCCCC---	43.97	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TMM51_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TMM51_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TMM51_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN5_HUMAN	PTPN5	physical	25416956
S39AB_HUMAN	SLC39A11	physical	26186194
HS12A_HUMAN	HSPA12A	physical	26186194
NEDD4_HUMAN	NEDD4	physical	26186194
ITCH_HUMAN	ITCH	physical	26186194
NED4L_HUMAN	NEDD4L	physical	26186194
WWP1_HUMAN	WWP1	physical	26186194
TTI1_HUMAN	TTI1	physical	26186194
PTER_HUMAN	PTER	physical	26186194
CT024_HUMAN	C20orf24	physical	26186194
AN13A_HUMAN	ANKRD13A	physical	26186194
FND3A_HUMAN	FNDC3A	physical	26186194
KBTB7_HUMAN	KBTBD7	physical	26186194
ZCCHL_HUMAN	ZC3HAV1L	physical	26186194
GALC_HUMAN	GALC	physical	26186194
F1142_HUMAN	FAM114A2	physical	26186194
PDCD4_HUMAN	PDCD4	physical	26186194
CUED1_HUMAN	CUEDC1	physical	26186194
HECW2_HUMAN	HECW2	physical	26186194
F1142_HUMAN	FAM114A2	physical	28514442
PDCD4_HUMAN	PDCD4	physical	28514442
NED4L_HUMAN	NEDD4L	physical	28514442
CT024_HUMAN	C20orf24	physical	28514442
NEDD4_HUMAN	NEDD4	physical	28514442
HS12A_HUMAN	HSPA12A	physical	28514442
PTER_HUMAN	PTER	physical	28514442
WWP1_HUMAN	WWP1	physical	28514442
TTI1_HUMAN	TTI1	physical	28514442
CUED1_HUMAN	CUEDC1	physical	28514442
ITCH_HUMAN	ITCH	physical	28514442
HECW2_HUMAN	HECW2	physical	28514442
GALC_HUMAN	GALC	physical	28514442
FND3A_HUMAN	FNDC3A	physical	28514442
S39AB_HUMAN	SLC39A11	physical	28514442
WWP2_HUMAN	WWP2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TMM51_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-234, AND MASSSPECTROMETRY.	19413330 [Abstract]