FCERG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FCERG_HUMAN
• UniProt AC: P30273
• Protein Name: High affinity immunoglobulin epsilon receptor subunit gamma
• Gene Name: FCER1G
• Organism: Homo sapiens (Human).
• Sequence Length: 86
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin..
• Protein Sequence: MIPAVVLLLLLLVEQAAALGEPQLCYILDAILFLYGIVLTLLYCRLKIQVRKAAITSYEKSDGVYTGLSTRNQETYETLKHEKPPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	QVRKAAITSYEKSDG HHHHHHHHEEECCCC	22.11	25219547
57	Phosphorylation	VRKAAITSYEKSDGV HHHHHHHEEECCCCC	25.77	25219547
58	Phosphorylation	RKAAITSYEKSDGVY HHHHHHEEECCCCCE	20.80	25219547
60	Ubiquitination	AAITSYEKSDGVYTG HHHHEEECCCCCEEC	45.68	21890473
61	Phosphorylation	AITSYEKSDGVYTGL HHHEEECCCCCEECC	27.88	29970186
65	Phosphorylation	YEKSDGVYTGLSTRN EECCCCCEECCCCCC	10.71	21082442
66	Phosphorylation	EKSDGVYTGLSTRNQ ECCCCCEECCCCCCH	29.28	20058876
69	Phosphorylation	DGVYTGLSTRNQETY CCCEECCCCCCHHHH	27.02	23401153
70	Phosphorylation	GVYTGLSTRNQETYE CCEECCCCCCHHHHH	38.39	29978859
75	Phosphorylation	LSTRNQETYETLKHE CCCCCHHHHHHHHCC	19.52	28857561
76	Phosphorylation	STRNQETYETLKHEK CCCCHHHHHHHHCCC	13.23	23911959
78	Phosphorylation	RNQETYETLKHEKPP CCHHHHHHHHCCCCC	30.60	23911959

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
69	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
69	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
69	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FCERG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FCERG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FCAR_HUMAN	FCAR	physical	15096494

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-65 AND TYR-76, AND MASSSPECTROMETRY.
PubMed: 18088087

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-65 AND TYR-76, AND MASSSPECTROMETRY.
PubMed: 18083107