FCAR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FCAR_HUMAN
• UniProt AC: P24071
• Protein Name: Immunoglobulin alpha Fc receptor
• Gene Name: FCAR
• Organism: Homo sapiens (Human).
• Sequence Length: 287
• Subcellular Localization: Isoform A.1: Cell membrane; Single-pass type I membrane protein.; Isoform A.2: Cell membrane; Single-pass type I membrane protein.; Isoform A.3: Cell membrane; Single-pass type I membrane protein.; Isoform B: Secreted.; Isoform B-delta-S2: Secreted.
• Protein Description: Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production..
• Protein Sequence: MDPKQTTLLCLVLCLGQRIQAQEGDFPMPFISAKSSPVIPLDGSVKIQCQAIREAYLTQLMIIKNSTYREIGRRLKFWNETDPEFVIDHMDANKAGRYQCQYRIGHYRFRYSDTLELVVTGLYGKPFLSADRGLVLMPGENISLTCSSAHIPFDRFSLAKEGELSLPQHQSGEHPANFSLGPVDLNVSGIYRCYGWYNRSPYLWSFPSNALELVVTDSIHQDYTTQNLIRMAVAGLVLVALLAILVENWHSHTALNKEASADVAEPSWSQQMCQPGLTFARTPSVCK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	PVIPLDGSVKIQCQA CEECCCCCEEEEHHH	21.65	22210691
56	Phosphorylation	CQAIREAYLTQLMII HHHHHHHHHHHHHHC	12.91	19664995
58	Phosphorylation	AIREAYLTQLMIIKN HHHHHHHHHHHHCCC	13.64	29978859
65	N-linked_Glycosylation	TQLMIIKNSTYREIG HHHHHCCCCCHHHHH	29.22	UniProtKB CARBOHYD
66	Phosphorylation	QLMIIKNSTYREIGR HHHHCCCCCHHHHHH	23.09	22210691
67	Phosphorylation	LMIIKNSTYREIGRR HHHCCCCCHHHHHHH	35.67	29978859
68	Phosphorylation	MIIKNSTYREIGRRL HHCCCCCHHHHHHHH	13.18	29978859
79	N-linked_Glycosylation	GRRLKFWNETDPEFV HHHHCCCCCCCCCCE	45.48	UniProtKB CARBOHYD
141	N-linked_Glycosylation	LVLMPGENISLTCSS EEEECCCCEEEEEEC	34.76	12768205
177	N-linked_Glycosylation	QSGEHPANFSLGPVD CCCCCCCCCEECCCC	31.33	12768205
186	N-linked_Glycosylation	SLGPVDLNVSGIYRC EECCCCCCCCCEEEE	22.80	UniProtKB CARBOHYD
198	N-linked_Glycosylation	YRCYGWYNRSPYLWS EEEECCCCCCCEEEE	31.29	UniProtKB CARBOHYD
223	Nitrated tyrosine	TDSIHQDYTTQNLIR CCCCCCCCHHHHHHH	12.71	-
223	Nitration	TDSIHQDYTTQNLIR CCCCCCCCHHHHHHH	12.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FCAR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FCAR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FCAR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FCGR1_HUMAN	FCGR1A	physical	8530370
LYN_HUMAN	LYN	physical	9427690
FCGR1_HUMAN	FCGR1A	physical	16517729
HUTH_HUMAN	HAL	physical	26186194
EFR3B_HUMAN	EFR3B	physical	26186194
FCERG_HUMAN	FCER1G	physical	15096494
EFR3B_HUMAN	EFR3B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Nitration

"The human pituitary nitroproteome: detection of nitrotyrosyl-proteinswith two-dimensional Western blotting, and amino acid sequencedetermination with mass spectrometry.";
Zhan X., Desiderio D.M.;
Biochem. Biophys. Res. Commun. 325:1180-1186(2004).
Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-223, AND MASS SPECTROMETRY.
PubMed: 15555551

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-56, AND MASSSPECTROMETRY.
PubMed: 18083107