IZUM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IZUM2_HUMAN
• UniProt AC: Q6UXV1
• Protein Name: Izumo sperm-egg fusion protein 2
• Gene Name: IZUMO2
• Organism: Homo sapiens (Human).
• Sequence Length: 221
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Sequence: MPLALTLLLLSGLGAPGGWGCLQCDPLVLEALGHLRSALIPSRFQLEQLQARAGAVLMGMEGPFFRDYALNVFVGKVETNQLDLVASFVKNQTQHLMGNSLKDEPLLEELVTLRANVIKEFKKVLISYELKACNPKLCRLLKEEVLDCLHCQRITPKCIHKKYCFVDRQPRVALQYQMDSKYPRNQALLGILISVSLAVFVFVVIVVSACTYRQNRKLLLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	NQLDLVASFVKNQTQ CCHHHHHHHHHHHHH	24.08	-
91	N-linked_Glycosylation	LVASFVKNQTQHLMG HHHHHHHHHHHHHCC	44.84	UniProtKB CARBOHYD
93	Phosphorylation	ASFVKNQTQHLMGNS HHHHHHHHHHHCCCC	27.61	17525332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IZUM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IZUM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IZUM2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of IZUM2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-93, AND MASSSPECTROMETRY.
PubMed: 17525332