GRM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRM2_HUMAN
• UniProt AC: Q14416
• Protein Name: Metabotropic glutamate receptor 2
• Gene Name: GRM2
• Organism: Homo sapiens (Human).
• Sequence Length: 872
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite.
• Protein Description: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization..
• Protein Sequence: MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	Phosphorylation	ALDFVRASLSRGADG HHHHHHHHHHCCCCC	19.13	27174698
111	Phosphorylation	DFVRASLSRGADGSR HHHHHHHHCCCCCCC	26.60	27174698
203	N-linked_Glycosylation	AEILRFFNWTYVSTV HHHHHHCCCEEEEEE	27.71	UniProtKB CARBOHYD
246	Phosphorylation	EKVGRAMSRAAFEGV HHHHHHHHHHHHHHH	20.13	-
286	N-linked_Glycosylation	LAASQRLNASFTWVA HHHHHHHCCCEEEEE	35.41	UniProtKB CARBOHYD
288	Phosphorylation	ASQRLNASFTWVASD HHHHHCCCEEEEECC	23.33	26853621
338	N-linked_Glycosylation	FQSLDPWNNSRNPWF HHHCCCCCCCCCHHH	41.82	UniProtKB CARBOHYD
402	N-linked_Glycosylation	MHRALCPNTTRLCDA HHHHHCCCHHHHHHH	53.75	UniProtKB CARBOHYD
457	Phosphorylation	IGRYNIFTYLRAGSG CCCCCCEEEEECCCC	20.18	-
501	Phosphorylation	PLPASRCSEPCLQNE CCCHHHCCCCHHHCC	43.39	-
547	N-linked_Glycosylation	CGLGYWPNASLTGCF CCCCCCCCCCEECCE	28.19	UniProtKB CARBOHYD
734	Phosphorylation	SMLGSLAYNVLLIAL HHHHHHHHHHHHHHH	15.88	-
745	Phosphorylation	LIALCTLYAFKTRKC HHHHHHHHHHHCCCC	7.58	-
749	Phosphorylation	CTLYAFKTRKCPENF HHHHHHHCCCCCCCC	28.98	-
850	Phosphorylation	SSSLGQGSGSQFVPT HHHCCCCCCCCCCCE	27.64	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBQL1_HUMAN	UBQLN1	physical	25416956
NADL2_HUMAN	NAALADL2	physical	25416956
GRIP1_HUMAN	GRIP1	physical	11891216
SDCB1_HUMAN	SDCBP	physical	11891216

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.