| UniProt ID | FHR5_HUMAN | |
|---|---|---|
| UniProt AC | Q9BXR6 | |
| Protein Name | Complement factor H-related protein 5 | |
| Gene Name | CFHR5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 569 | |
| Subcellular Localization | Secreted. | |
| Protein Description | Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH.. | |
| Protein Sequence | MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQEGKFEYPICE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 126 | N-linked_Glycosylation | SLQNNEKNISCVERG HHCCCCCCEEEECCC | 25.81 | UniProtKB CARBOHYD | |
| 135 | Phosphorylation | SCVERGWSTPPICSF EEECCCCCCCCCCCC | 33.58 | 23532336 | |
| 141 | Phosphorylation | WSTPPICSFTKGECH CCCCCCCCCCCCEEE | 36.35 | 24719451 | |
| 165 | Phosphorylation | AQPKKESYKVGDVLK CCCCCCCCCCCCCEE | 15.70 | - | |
| 186 | Phosphorylation | LIRVGSDSVQCYQFG EEEECCCCEEEEECC | 18.78 | - | |
| 200 | Phosphorylation | GWSPNFPTCKGQVRS CCCCCCCCCCCCHHC | 23.78 | - | |
| 283 | O-linked_Glycosylation | EYGYVQPSVPPYQHG EEEEECCCCCCCCCC | 30.11 | OGP | |
| 345 | Phosphorylation | IKTLLKLSGKEFNHN HHHHHHHCCCCCCCC | 46.35 | 29391485 | |
| 400 | N-linked_Glycosylation | PQIPNAQNMTTTVNY CCCCCCCCCEEEEEC | 27.62 | UniProtKB CARBOHYD | |
| 421 | Phosphorylation | AVLCKENYLLPEAKE EEEEECCCCCCCCEE | 15.65 | - | |
| 480 | Phosphorylation | TVTYRCQSFYKLQGS EEEEECCCEEEEECE | 33.88 | 29083192 | |
| 482 | Phosphorylation | TYRCQSFYKLQGSVT EEECCCEEEEECEEE | 18.94 | 29083192 | |
| 487 | Phosphorylation | SFYKLQGSVTVTCRN CEEEEECEEEEEECC | 11.14 | 29083192 | |
| 489 | Phosphorylation | YKLQGSVTVTCRNKQ EEEECEEEEEECCCC | 16.28 | 29083192 | |
| 491 | Phosphorylation | LQGSVTVTCRNKQWS EECEEEEEECCCCCC | 9.07 | 29083192 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FHR5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FHR5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FHR5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of FHR5_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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