TNF12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNF12_HUMAN
• UniProt AC: O43508
• Protein Name: Tumor necrosis factor ligand superfamily member 12
• Gene Name: TNFSF12
• Organism: Homo sapiens (Human).
• Sequence Length: 249
• Subcellular Localization: Cell membrane ; Single-pass type II membrane protein .; Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted.; Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein.
• Protein Description: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion..
• Protein Sequence: MAARRSQRRRGRRGEPGTALLVPLALGLGLALACLGLLLAVVSLGSRASLSAQEPAQEELVAEEDQDPSELNPQTEESQDPAPFLNRLVRPRRSAPKGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDGVLALRCLEEFSATAASSLGPQLRLCQVSGLLALRPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
139	N-linked_Glycosylation	GWEEARINSSSPLRY CCCCCCCCCCCCCCC	30.22	UniProtKB CARBOHYD
198	O-linked_Glycosylation	CLEEFSATAASSLGP HHHHHCCHHHHHCCH	22.89	OGP
213	Phosphorylation	QLRLCQVSGLLALRP HHHEEEECCEEEECC	9.61	-
222	Phosphorylation	LLALRPGSSLRIRTL EEEECCCCCCEEEEC	28.96	23312004
223	Phosphorylation	LALRPGSSLRIRTLP EEECCCCCCEEEECC	27.81	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNF12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNF12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNF12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OTUB1_HUMAN	OTUB1	physical	23524849
BIRC2_HUMAN	BIRC2	physical	23524849
TRAF2_HUMAN	TRAF2	physical	23524849
TN13B_HUMAN	TNFSF13B	physical	23493554

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.