| UniProt ID | TN13B_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y275 | |
| Protein Name | Tumor necrosis factor ligand superfamily member 13B | |
| Gene Name | TNFSF13B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 285 | |
| Subcellular Localization |
Cell membrane Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted. |
|
| Protein Description | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.; Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.. | |
| Protein Sequence | MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 41 | Phosphorylation | KESPSVRSSKDGKLL CCCCCCCCCCCCHHH | 39.31 | - | |
| 78 | Phosphorylation | ALQGDLASLRAELQG HHCCCHHHHHHHHCC | 26.19 | 24719451 | |
| 124 | N-linked_Glycosylation | PPAPGEGNSSQNSRN CCCCCCCCCCCCHHC | 33.90 | UniProtKB CARBOHYD | |
| 124 | N-linked_Glycosylation | PPAPGEGNSSQNSRN CCCCCCCCCCCCHHC | 33.90 | 10359578 | |
| 171 | Phosphorylation | TFVPWLLSFKRGSAL EEHHHHHHCCCCCCC | 26.93 | 24719451 | |
| 184 | Acetylation | ALEEKENKILVKETG CCHHHHCCEEEECCE | 38.21 | 7823391 | |
| 204 | Acetylation | GQVLYTDKTYAMGHL EEEEECCCCHHHHHH | 35.32 | 7823401 | |
| 242 | N-linked_Glycosylation | NMPETLPNNSCYSAG CCCCCCCCCCCEECC | 57.04 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TN13B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TN13B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TN13B_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| D03068 | Belimumab (genetical recombination) (JAN); Belimumab (USAN); Benlysta (TN); LymphoStat-B (TN) | |||||
| D08877 | Briobacept (USAN) | |||||
| D09704 | Atacicept (USAN/INN) | |||||
| D10083 | Tabalumab (USAN) | |||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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