| UniProt ID | TNF13_HUMAN | |
|---|---|---|
| UniProt AC | O75888 | |
| Protein Name | Tumor necrosis factor ligand superfamily member 13 | |
| Gene Name | TNFSF13 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 250 | |
| Subcellular Localization | Secreted . | |
| Protein Description | Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.. | |
| Protein Sequence | MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MPASSPFLLAP ----CCCCCCCEECC | 32.45 | 23312004 | |
| 5 | Phosphorylation | ---MPASSPFLLAPK ---CCCCCCCEECCC | 23.06 | 25159151 | |
| 108 | Phosphorylation | RKRRAVLTQKQKKQH HHHHHHHCHHHHHCC | 27.41 | - | |
| 110 | Ubiquitination | RRAVLTQKQKKQHSV HHHHHCHHHHHCCCE | 59.87 | - | |
| 124 | N-linked_Glycosylation | VLHLVPINATSKDDS EEEEEECCCCCCCCC | 30.97 | UniProtKB CARBOHYD | |
| 153 | Phosphorylation | RGLQAQGYGVRIQDA CCCCCCCCCEEEHHH | 10.60 | - | |
| 212 | Phosphorylation | DRAYNSCYSAGVFHL CHHHHCHHCCEEEEE | 11.02 | 19276368 | |
| 213 | Phosphorylation | RAYNSCYSAGVFHLH HHHHCHHCCEEEEEC | 23.91 | 19276368 | |
| 226 | Phosphorylation | LHQGDILSVIIPRAR ECCCCEEEEEECHHH | 16.17 | 19276368 | |
| 239 | Phosphorylation | ARAKLNLSPHGTFLG HHHHCCCCCCCCEEE | 17.49 | 29083192 | |
| 243 | Phosphorylation | LNLSPHGTFLGFVKL CCCCCCCCEEEEEEC | 16.80 | 29083192 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TNF13_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TNF13_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TNF13_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TNF13_HUMAN | TNFSF13 | physical | 12370363 | |
| TN13B_HUMAN | TNFSF13B | physical | 12370363 | |
| TNR1A_HUMAN | TNFRSF1A | physical | 10706119 | |
| TNR14_HUMAN | TNFRSF14 | physical | 10706119 | |
| TNR6_HUMAN | FAS | physical | 10706119 | |
| TR11B_HUMAN | TNFRSF11B | physical | 10706119 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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