TR11B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TR11B_HUMAN
• UniProt AC: O00300
• Protein Name: Tumor necrosis factor receptor superfamily member 11B
• Gene Name: TNFRSF11B
• Organism: Homo sapiens (Human).
• Sequence Length: 401
• Subcellular Localization: Secreted.
• Protein Description: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis..
• Protein Sequence: MNNLLCCALVFLDISIKWTTQETFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAKWKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHNRVCECKEGRYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFGLLLTQKGNATHDNICSGNSESTQKCGIDVTLCEEAFFRFAVPTKFTPNWLSVLVDNLPGTKVNAESVERIKRQHSSQEQTFQLLKLWKHQNKDQDIVKKIIQDIDLCENSVQRHIGHANLTFEQLRSLMESLPGKKVGAEDIEKTIKACKPSDQILKLLSLWRIKNGDQDTLKGLMHALKHSKTYHFPKTVTQSLKKTIRFLHSFTMYKLYQKLFLEMIGNQVQSVKISCL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	CAPCPDHYYTDSWHT EEECCCCCCCCCCCC	18.55	30576142
70	Phosphorylation	APCPDHYYTDSWHTS EECCCCCCCCCCCCC	10.72	30576142
77	Phosphorylation	YTDSWHTSDECLYCS CCCCCCCCCCCEECC	20.65	30576142
98	N-linked_Glycosylation	QYVKQECNRTHNRVC HHHHHHHHCCCCCEE	51.65	UniProtKB CARBOHYD
152	N-linked_Glycosylation	CPDGFFSNETSSKAP CCCCCCCCCCCCCCC	51.95	UniProtKB CARBOHYD
154	Phosphorylation	DGFFSNETSSKAPCR CCCCCCCCCCCCCCC	42.42	30206219
155	Phosphorylation	GFFSNETSSKAPCRK CCCCCCCCCCCCCCC	24.54	30206219
156	Phosphorylation	FFSNETSSKAPCRKH CCCCCCCCCCCCCCC	40.01	30206219
165	N-linked_Glycosylation	APCRKHTNCSVFGLL CCCCCCCCCCHHEEE	18.78	UniProtKB CARBOHYD
178	N-linked_Glycosylation	LLLTQKGNATHDNIC EEEEECCCCCCCCCC	49.02	22664871
236	Phosphorylation	GTKVNAESVERIKRQ CCCCCHHHHHHHHHH	27.20	22210691
245	Phosphorylation	ERIKRQHSSQEQTFQ HHHHHHCCCHHHHHH	25.94	24043423
246	Phosphorylation	RIKRQHSSQEQTFQL HHHHHCCCHHHHHHH	35.30	24043423
250	Phosphorylation	QHSSQEQTFQLLKLW HCCCHHHHHHHHHHH	16.76	24043423
289	N-linked_Glycosylation	QRHIGHANLTFEQLR HHHHCCCCCCHHHHH	33.66	UniProtKB CARBOHYD
330	Phosphorylation	DQILKLLSLWRIKNG HHHHHHHHHHHCCCC	36.00	24719451
360	Phosphorylation	KTYHFPKTVTQSLKK CCCCCCHHHHHHHHH	29.08	-
362	Phosphorylation	YHFPKTVTQSLKKTI CCCCHHHHHHHHHHH	20.06	-
364	Phosphorylation	FPKTVTQSLKKTIRF CCHHHHHHHHHHHHH	32.56	-
368	Phosphorylation	VTQSLKKTIRFLHSF HHHHHHHHHHHHHHH	18.79	29396449
374	Phosphorylation	KTIRFLHSFTMYKLY HHHHHHHHHHHHHHH	25.26	29396449
376	Phosphorylation	IRFLHSFTMYKLYQK HHHHHHHHHHHHHHH	23.70	29396449
378	Phosphorylation	FLHSFTMYKLYQKLF HHHHHHHHHHHHHHH	8.52	29396449

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TR11B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TR11B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TR11B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNF11_HUMAN	TNFSF11	physical	9520411

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.