TNF11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNF11_HUMAN
• UniProt AC: O14788
• Protein Name: Tumor necrosis factor ligand superfamily member 11
• Gene Name: TNFSF11
• Organism: Homo sapiens (Human).
• Sequence Length: 317
• Subcellular Localization: Isoform 1: Cell membrane; Single-pass type II membrane protein.; Isoform 3: Cell membrane; Single-pass type II membrane protein.; Isoform 2: Cytoplasm.; Tumor necrosis factor ligand superfamily member 11, soluble form: Secreted.
• Protein Description: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. [PubMed: 22664871 Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity]
• Protein Sequence: MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
137	Phosphorylation	ELQHIVGSQHIRAEK HHHHHHCCHHHEEEE	14.00	-
171	N-linked_Glycosylation	PFAHLTINATDIPSG CCCEEEEECCCCCCC	31.39	UniProtKB CARBOHYD
198	N-linked_Glycosylation	RGWAKISNMTFSNGK CCEEEEEEEEEECCE	36.67	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNF11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNF11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNF11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRC_HUMAN	SRC	physical	10635328
ZN675_HUMAN	ZNF675	genetic	11751921
PLK1_HUMAN	PLK1	physical	21900206
DDAH2_HUMAN	DDAH2	physical	21900206
PGFS_HUMAN	FAM213B	physical	21900206
TMOD3_HUMAN	TMOD3	physical	21900206
LMO4_HUMAN	LMO4	physical	21900206
TRM2A_HUMAN	TRMT2A	physical	21900206
MED24_HUMAN	MED24	physical	21900206
BBS10_HUMAN	BBS10	physical	21900206
U1SBP_HUMAN	SNRNP35	physical	21900206
CE126_HUMAN	KIAA1377	physical	21900206
MTMR5_HUMAN	SBF1	physical	21900206
PHAX_HUMAN	PHAX	physical	21900206
MBTP1_HUMAN	MBTPS1	physical	21900206
EF1A1_HUMAN	EEF1A1	physical	21900206
NIPA_HUMAN	ZC3HC1	physical	21900206
EZH2_HUMAN	EZH2	physical	21900206
GALT7_HUMAN	GALNT7	physical	26186194
GOSR1_HUMAN	GOSR1	physical	26186194
AT5G1_HUMAN	ATP5G1	physical	26186194
NU1M_HUMAN	ND1	physical	26186194
DNJB9_HUMAN	DNAJB9	physical	26186194
B4GT7_HUMAN	B4GALT7	physical	26186194
GOSR1_HUMAN	GOSR1	physical	28514442
AT5G1_HUMAN	ATP5G1	physical	28514442
DNJB9_HUMAN	DNAJB9	physical	28514442
NU1M_HUMAN	ND1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.