KIF12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIF12_HUMAN
• UniProt AC: Q96FN5
• Protein Name: Kinesin-like protein KIF12
• Gene Name: KIF12
• Organism: Homo sapiens (Human).
• Sequence Length: 646
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Sequence: MEERGSPDGDLARSLEQGPEGPETPIQVVLRVRPMSAAELRRGQQSVLHCSGTRTLQGGPEVAFRFGAVLDAARTQEDVFRACGVRRLGELALRGFSCTVFTFGQTGSGKTYTLTGPPPQGEGVPVPPSLAGIMQRTFAWLLDRVQHLGAPVTLRASYLEIYNEQVRDLLSLGSPRPLPVRWNKTRGFYVEQLRVVEFGSLEALMELLQTGLSRRRNSAHTLNQASSRSHALLTLYISRQTAQQMPSVDPGEPPVGGKLCFVDLAGSEKVAATGSRGELMLEANSINRSLLALGHCISLLLDPQRKQSHIPFRDSKLTKLLADSLGGRGVTLMVACVSPSAQCLPETLSTLRYASRAQRVTTRPQAPKSPVAKQPQRLETEMLQLQEENRRLQFQLDQMDCKASGLSGARVAWAQRNLYGMLQEFMLENERLRKEKSQLQNSRDLAQNEQRILAQQVHALERRLLSACYHHQQGPGLTPPCPCLMAPAPPCHALPPLYSCPCCHICPLCRVPLAHWACLPGEHHLPQVLDPEASGGRPPSARPPPWAPPCSPGSAKCPRERSHSDWTQTRVLAEMLTEEEVVPSAPPLPVRPPKTSPGLRGGAGVPNLAQRLEALRDQIGSSLRRGRSQPPCSEGARSPGQVLPPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEERGSPDGDLAR --CCCCCCCCCHHHH	26.49	28857561
14	Phosphorylation	PDGDLARSLEQGPEG CCCHHHHHHHCCCCC	30.56	29759185
36	Phosphorylation	VLRVRPMSAAELRRG EEEECCCCHHHHHCC	27.32	23312004
41	Phosphorylation	PMSAAELRRGQQSVL CCCHHHHHCCCCCEE	31.99	27251275
85	Phosphorylation	DVFRACGVRRLGELA HHHHHHCCHHHHHHH	3.03	27251275
171	Phosphorylation	EQVRDLLSLGSPRPL HHHHHHHHCCCCCCC	37.67	28857561
174	Phosphorylation	RDLLSLGSPRPLPVR HHHHHCCCCCCCCCC	24.03	29759185
210	Phosphorylation	ALMELLQTGLSRRRN HHHHHHHHCHHHHHC	39.81	29083192
213	Phosphorylation	ELLQTGLSRRRNSAH HHHHHCHHHHHCCHH	25.70	29083192
218	Phosphorylation	GLSRRRNSAHTLNQA CHHHHHCCHHHHHHH	21.44	29759185
234	Phosphorylation	SRSHALLTLYISRQT HHHHHHHHHHHCHHH	20.54	-
236	Phosphorylation	SHALLTLYISRQTAQ HHHHHHHHHCHHHHH	7.51	27251275
285	Phosphorylation	ELMLEANSINRSLLA CCHHHHHHHCHHHHH	28.43	29759185
362	Phosphorylation	SRAQRVTTRPQAPKS HHHHHCCCCCCCCCC	37.18	25072903
369	Phosphorylation	TRPQAPKSPVAKQPQ CCCCCCCCCCCCCCH	24.45	28857561
401	Phosphorylation	FQLDQMDCKASGLSG HHHHHHHHHHCCCCH	3.13	27251275
404	Phosphorylation	DQMDCKASGLSGARV HHHHHHHCCCCHHHH	26.26	29759185
407	Phosphorylation	DCKASGLSGARVAWA HHHHCCCCHHHHHHH	33.65	29759185
431	Phosphorylation	EFMLENERLRKEKSQ HHHHHHHHHHHHHHH	51.91	27251275
463	Phosphorylation	QVHALERRLLSACYH HHHHHHHHHHHHHHH	30.52	27251275
505	Phosphorylation	YSCPCCHICPLCRVP CCCCCCCCCHHCCCC	1.29	27251275
534	Phosphorylation	QVLDPEASGGRPPSA CCCCCCCCCCCCCCC	39.87	27251275
540	Phosphorylation	ASGGRPPSARPPPWA CCCCCCCCCCCCCCC	39.32	29759185
551	Phosphorylation	PPWAPPCSPGSAKCP CCCCCCCCCCCCCCC	37.76	29759185
554	Phosphorylation	APPCSPGSAKCPRER CCCCCCCCCCCCCCC	28.12	29759185
562	Phosphorylation	AKCPRERSHSDWTQT CCCCCCCCCCCHHHH	23.69	29759185
564	Phosphorylation	CPRERSHSDWTQTRV CCCCCCCCCHHHHHH	35.77	28857561
569	Phosphorylation	SHSDWTQTRVLAEML CCCCHHHHHHHHHHC	18.51	29759185
595	Phosphorylation	LPVRPPKTSPGLRGG CCCCCCCCCCCCCCC	46.02	27251275
596	Phosphorylation	PVRPPKTSPGLRGGA CCCCCCCCCCCCCCC	24.09	29759185
628	Phosphorylation	SSLRRGRSQPPCSEG HHHHCCCCCCCCCCC	50.27	29759185
638	Phosphorylation	PCSEGARSPGQVLPP CCCCCCCCCCCCCCC	32.61	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KIF12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIF12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIF12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLPX_HUMAN	CLPX	physical	26186194
MMAD_HUMAN	MMADHC	physical	26186194
MMAD_HUMAN	MMADHC	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.