SFT2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SFT2B_HUMAN
• UniProt AC: O95562
• Protein Name: Vesicle transport protein SFT2B
• Gene Name: SFT2D2 {ECO:0000312|EMBL:AAH68098.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 160
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex..
• Protein Sequence: MDKLKKVLSGQDTEDRSGLSEVVEASSLSWSTRIKGFIACFAIGILCSLLGTVLLWVPRKGLHLFAVFYTFGNIASIGSTIFLMGPVKQLKRMFEPTRLIATIMVLLCFALTLCSAFWWHNKGLALIFCILQSLALTWYSLSFIPFARDAVKKCFAVCLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDKLKKVL -------CCHHHHHH	10.40	22814378
3	Ubiquitination	-----MDKLKKVLSG -----CCHHHHHHCC	61.99	23000965
5	Ubiquitination	---MDKLKKVLSGQD ---CCHHHHHHCCCC	46.72	23000965
6	Ubiquitination	--MDKLKKVLSGQDT --CCHHHHHHCCCCC	59.86	23000965
9	Phosphorylation	DKLKKVLSGQDTEDR CHHHHHHCCCCCCCC	37.08	23911959
13	Phosphorylation	KVLSGQDTEDRSGLS HHHCCCCCCCCCCHH	31.71	23911959
17	Phosphorylation	GQDTEDRSGLSEVVE CCCCCCCCCHHHHHH	57.30	28270605
20	Phosphorylation	TEDRSGLSEVVEASS CCCCCCHHHHHHHHH	31.69	28270605
26	Phosphorylation	LSEVVEASSLSWSTR HHHHHHHHHCCHHHH	20.50	22210691
29	Phosphorylation	VVEASSLSWSTRIKG HHHHHHCCHHHHHHH	22.41	22210691
32	Phosphorylation	ASSLSWSTRIKGFIA HHHCCHHHHHHHHHH	30.10	-
154	S-palmitoylation	ARDAVKKCFAVCLA- HHHHHHHHHHHHHC-	1.88	29575903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SFT2B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SFT2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SFT2B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SFT2B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND MASSSPECTROMETRY.
PubMed: 19690332