ABCA9_HUMAN - dbPTM
ABCA9_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABCA9_HUMAN
UniProt AC Q8IUA7
Protein Name ATP-binding cassette sub-family A member 9
Gene Name ABCA9
Organism Homo sapiens (Human).
Sequence Length 1624
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description May play a role in monocyte differentiation and lipid homeostasis..
Protein Sequence MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQMSSMDLGRVDSFNDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELDLNYSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVSITTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNTYFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAIIVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEHMDYEYGYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEISPDSMDYLGASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDLEEDFDPSVKWKLLLQEEP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
30PhosphorylationKWRMKRQTLLEWLFS
HHHHHHHHHHHHHHH		37.0324043423
37PhosphorylationTLLEWLFSFLLVLFL
HHHHHHHHHHHHHHH		16.8924043423
45PhosphorylationFLLVLFLYLFFSNLH
HHHHHHHHHHHHCHH		8.3024043423
49PhosphorylationLFLYLFFSNLHQVHD
HHHHHHHHCHHHCCC		31.0224043423
57PhosphorylationNLHQVHDTPQMSSMD
CHHHCCCCCCCCCCC		10.6724043423
61PhosphorylationVHDTPQMSSMDLGRV
CCCCCCCCCCCCCCC		19.7724043423
62PhosphorylationHDTPQMSSMDLGRVD
CCCCCCCCCCCCCCC		15.8024043423
120N-linked_GlycosylationSMDELDLNYSIDAVR
CCCHHCCCCEEEEEE		28.33UniProtKB CARBOHYD
195N-linked_GlycosylationAIIEIATNHSVMEQL
HHHHHHHCCHHHHHH		19.20UniProtKB CARBOHYD
251PhosphorylationNVTQERQYITSLMTM
CCCHHHHHHHHHHHH		16.6424043423
253PhosphorylationTQERQYITSLMTMMG
CHHHHHHHHHHHHHC		15.7524043423
254PhosphorylationQERQYITSLMTMMGL
HHHHHHHHHHHHHCH		13.4424043423
257PhosphorylationQYITSLMTMMGLRES
HHHHHHHHHHCHHHH		14.8624043423
524PhosphorylationGHSGAGKTTLLNILS
CCCCCCHHHHHHHHC		23.0428857561
525PhosphorylationHSGAGKTTLLNILSG
CCCCCHHHHHHHHCC		32.5028857561
544PhosphorylationTSGSVTVYNHTLSRM
CCCCEEEEECCHHHH		7.5828857561
549PhosphorylationTVYNHTLSRMADIEN
EEEECCHHHHHCCCC		22.5928857561
835PhosphorylationSFHETRKTISGVALW
HHHHHCCHHCHHHHH		19.6546156591
837PhosphorylationHETRKTISGVALWRQ
HHHCCHHCHHHHHHH		32.2346156581
949N-linked_GlycosylationVDAFGTRNGTDDPSY
EECCCCCCCCCCCCC		58.5119159218
1090PhosphorylationLLMQIMDYIFSPEEI
HHHHHHHHCCCHHHH		6.1046156595
1333PhosphorylationGHNGAGKSTTIKMIT
CCCCCCCCEEEEEEC		29.8429978859
1334PhosphorylationHNGAGKSTTIKMITG
CCCCCCCEEEEEECC		35.7129978859
1335PhosphorylationNGAGKSTTIKMITGD
CCCCCCEEEEEECCC		26.2029978859
1340PhosphorylationSTTIKMITGDTKPTA
CEEEEEECCCCCCCC		26.0529978859
1343PhosphorylationIKMITGDTKPTAGQV
EEEECCCCCCCCCEE		40.0229978859
1346PhosphorylationITGDTKPTAGQVILK
ECCCCCCCCCEEEEE		45.0029978859
1420PhosphorylationQLKAPVKTLSEGIKR
HHCCCHHHHCHHHHH		35.43-
1496PhosphorylationDRVAIMVSGRLRCIG
CHHHHECCCCHHHHH		10.7923612710
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABCA9_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABCA9_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABCA9_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ABCA9_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABCA9_HUMAN

loading...

Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-949, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory