CLC4A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLC4A_HUMAN
• UniProt AC: Q9UMR7
• Protein Name: C-type lectin domain family 4 member A {ECO:0000305}
• Gene Name: CLEC4A {ECO:0000312|HGNC:HGNC:13257}
• Organism: Homo sapiens (Human).
• Sequence Length: 237
• Subcellular Localization: Cell membrane ; Single-pass type II membrane protein ; Extracellular side .
• Protein Description: C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. [PubMed: 27015765 Involved in regulating immune reactivity]
• Protein Sequence: MTSEITYAEVRFKNEFKSSGINTASSAASKERTAPHKSNTGFPKLLCASLLIFFLLLAISFFIAFVIFFQKYSQLLEKKTTKELVHTTLECVKKNMPVEETAWSCCPKNWKSFSSNCYFISTESASWQDSEKDCARMEAHLLVINTQEEQDFIFQNLQEESAYFVGLSDPEGQRHWQWVDQTPYNESSTFWHPREPSDPNERCVVLNFRKSPKRWGWNDVNCLGPQRSVCEMMKIHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSEITYAE ------CCCCEEEEE	34.76	27732954
3	Phosphorylation	-----MTSEITYAEV -----CCCCEEEEEE	26.21	27732954
18	Phosphorylation	RFKNEFKSSGINTAS EECHHHHHCCCCCCC	38.83	27486199
19	Phosphorylation	FKNEFKSSGINTASS ECHHHHHCCCCCCCC	44.26	27486199
23	Phosphorylation	FKSSGINTASSAASK HHHCCCCCCCCHHHC	26.46	27486199
25	Phosphorylation	SSGINTASSAASKER HCCCCCCCCHHHCCC	20.62	27486199
26	Phosphorylation	SGINTASSAASKERT CCCCCCCCHHHCCCC	25.95	27486199
29	Phosphorylation	NTASSAASKERTAPH CCCCCHHHCCCCCCC	34.46	27486199
72	Phosphorylation	FVIFFQKYSQLLEKK HHHHHHHHHHHHCHH	7.29	24702127
73	Phosphorylation	VIFFQKYSQLLEKKT HHHHHHHHHHHCHHC	22.76	24702127
101	Phosphorylation	KNMPVEETAWSCCPK HCCCHHHHCHHCCCC	21.66	29083192
104	Phosphorylation	PVEETAWSCCPKNWK CHHHHCHHCCCCCCC	11.90	29083192
185	N-linked_Glycosylation	WVDQTPYNESSTFWH ECCCCCCCCCCCCCC	43.83	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLC4A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLC4A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLC4A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CLC4A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.