dbPTM

CLCA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CLCA4_HUMAN
UniProt AC	Q14CN2
Protein Name	Calcium-activated chloride channel regulator 4
Gene Name	CLCA4
Organism	Homo sapiens (Human).
Sequence Length	919
Subcellular Localization	Cell membrane Single-pass membrane protein. Apical cell membrane. Secreted. The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus..
Protein Description	May be involved in mediating calcium-activated chloride conductance..
Protein Sequence	MGLFRGFVFLLVLCLLHQSNTSFIKLNNNGFEDIVIVIDPSVPEDEKIIEQIEDMVTTASTYLFEATEKRFFFKNVSILIPENWKENPQYKRPKHENHKHADVIVAPPTLPGRDEPYTKQFTECGEKGEYIHFTPDLLLGKKQNEYGPPGKLFVHEWAHLRWGVFDEYNEDQPFYRAKSKKIEATRCSAGISGRNRVYKCQGGSCLSRACRIDSTTKLYGKDCQFFPDKVQTEKASIMFMQSIDSVVEFCNEKTHNQEAPSLQNIKCNFRSTWEVISNSEDFKNTIPMVTPPPPPVFSLLKISQRIVCLVLDKSGSMGGKDRLNRMNQAAKHFLLQTVENGSWVGMVHFDSTATIVNKLIQIKSSDERNTLMAGLPTYPLGGTSICSGIKYAFQVIGELHSQLDGSEVLLLTDGEDNTASSCIDEVKQSGAIVHFIALGRAADEAVIEMSKITGGSHFYVSDEAQNNGLIDAFGALTSGNTDLSQKSLQLESKGLTLNSNAWMNDTVIIDSTVGKDTFFLITWNSLPPSISLWDPSGTIMENFTVDATSKMAYLSIPGTAKVGTWAYNLQAKANPETLTITVTSRAANSSVPPITVNAKMNKDVNSFPSPMIVYAEILQGYVPVLGANVTAFIESQNGHTEVLELLDNGAGADSFKNDGVYSRYFTAYTENGRYSLKVRAHGGANTARLKLRPPLNRAAYIPGWVVNGEIEANPPRPEIDEDTQTTLEDFSRTASGGAFVVSQVPSLPLPDQYPPSQITDLDATVHEDKIILTWTAPGDNFDVGKVQRYIIRISASILDLRDSFDDALQVNTTDLSPKEANSKESFAFKPENISEENATHIFIAIKSIDKSNLTSKVSNIAQVTLFIPQANPDDIDPTPTPTPTPTPDKSHNSGVNISTLVLSVIGSVVIVNFILSTTI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	LLHQSNTSFIKLNNN HHHHCCCCEEEECCC	29.26	24719451
75	N-linked_Glycosylation	EKRFFFKNVSILIPE CCEEEEECEEEECCC	27.84	UniProtKB CARBOHYD
90	Phosphorylation	NWKENPQYKRPKHEN CCCCCCCCCCCCCCC	15.38	29978859
109	Phosphorylation	DVIVAPPTLPGRDEP CEEECCCCCCCCCCC	44.52	28111955
134	Phosphorylation	KGEYIHFTPDLLLGK CCCEEEECHHHHCCC	11.17	22210691
236	Phosphorylation	KVQTEKASIMFMQSI CHHCCHHHHHHHHHH	26.17	-
298	Phosphorylation	PPPPPVFSLLKISQR CCCCCCHHHHHHCCE	32.78	24719451
340	N-linked_Glycosylation	FLLQTVENGSWVGMV HHEEECCCCCEEEEE	45.52	UniProtKB CARBOHYD
364	Phosphorylation	NKLIQIKSSDERNTL HHHHCCCCCCCCCCE	44.65	-
504	N-linked_Glycosylation	LNSNAWMNDTVIIDS ECCCCCCCCEEEEEC	30.97	UniProtKB CARBOHYD
542	N-linked_Glycosylation	PSGTIMENFTVDATS CCCCEECCEEEECCC	22.10	UniProtKB CARBOHYD
588	N-linked_Glycosylation	TVTSRAANSSVPPIT EEEECCCCCCCCCEE	33.56	UniProtKB CARBOHYD
589	Phosphorylation	VTSRAANSSVPPITV EEECCCCCCCCCEEE	28.17	-
628	N-linked_Glycosylation	YVPVLGANVTAFIES CCCEECCEEEEEEEC	29.85	UniProtKB CARBOHYD
675	Phosphorylation	YTENGRYSLKVRAHG EECCCCEEEEEEECC	21.98	24719451
803	Phosphorylation	SILDLRDSFDDALQV HHHHHHHHHCCCCCC	24.92	18491316
811	N-linked_Glycosylation	FDDALQVNTTDLSPK HCCCCCCCCCCCCHH	25.05	16740002
832	N-linked_Glycosylation	SFAFKPENISEENAT CCCCCCCCCCHHCCC	52.17	UniProtKB CARBOHYD
837	N-linked_Glycosylation	PENISEENATHIFIA CCCCCHHCCCEEEEE	46.19	UniProtKB CARBOHYD
852	N-linked_Glycosylation	IKSIDKSNLTSKVSN EEEECCCCCHHHHCC	53.75	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CLCA4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CLCA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CLCA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CLCA4_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D08275	Niflumic acid (INN); Niflugel (TN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CLCA4_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Identification of N-linked glycoproteins in human saliva byglycoprotein capture and mass spectrometry."; Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T.,Loo J.A.; J. Proteome Res. 5:1493-1503(2006). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-811, AND MASSSPECTROMETRY.	16740002 [Abstract]