dbPTM

DS13B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DS13B_HUMAN
UniProt AC	Q9UII6
Protein Name	Dual specificity protein phosphatase 13 isoform B
Gene Name	DUSP13
Organism	Homo sapiens (Human).
Sequence Length	198
Subcellular Localization
Protein Description	Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro..
Protein Sequence	MDSLQKQDLRRPKIHGAVQASPYQPPTLASLQRLLWVRQAATLNHIDEVWPSLFLGDAYAARDKSKLIQLGITHVVNAAAGKFQVDTGAKFYRGMSLEYYGIEADDNPFFDLSVYFLPVARYIRAALSVPQGRVLVHCAMGVSRSATLVLAFLMICENMTLVEAIQTVQAHRNICPNSGFLRQLQVLDNRLGRETGRF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
122	Phosphorylation	YFLPVARYIRAALSV EHHHHHHHHHHHHCC	-
145	Phosphorylation	CAMGVSRSATLVLAF HCCCCCHHHHHHHHH	24719451
160	Phosphorylation	LMICENMTLVEAIQT HHHHCCCCHHHHHHH	24719451
167	Phosphorylation	TLVEAIQTVQAHRNI CHHHHHHHHHHHHCC	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DS13B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DS13B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DS13B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CACO1_HUMAN	CALCOCO1	physical	25416956
CARD9_HUMAN	CARD9	physical	25416956
ANAG_HUMAN	NAGLU	physical	27880917
NUP98_HUMAN	NUP98	physical	27880917
NU107_HUMAN	NUP107	physical	27880917
FTM_HUMAN	RPGRIP1L	physical	27880917
DS13A_HUMAN	DUSP13	physical	27432908
DS13B_HUMAN	DUSP13	physical	27432908
DCTP1_HUMAN	DCTPP1	physical	27432908
DRB5_HUMAN	HLA-DRB5	physical	27432908
KCTD6_HUMAN	KCTD6	physical	27432908
ISCA2_HUMAN	ISCA2	physical	27432908
PDE4D_HUMAN	PDE4D	physical	27432908
PITH1_HUMAN	PITHD1	physical	27432908
NFU1_HUMAN	NFU1	physical	27432908
ACOT9_HUMAN	ACOT9	physical	27432908
NCOA2_HUMAN	NCOA2	physical	27432908
NT5D2_HUMAN	NT5DC2	physical	27432908
IPYR_HUMAN	PPA1	physical	27432908
PTN11_HUMAN	PTPN11	physical	27432908
WIPI3_HUMAN	WDR45B	physical	27432908
DCTN3_HUMAN	DCTN3	physical	27432908
OTUD5_HUMAN	OTUD5	physical	27432908
LACRT_HUMAN	LACRT	physical	27432908
DCTN1_HUMAN	DCTN1	physical	27432908
DCTN2_HUMAN	DCTN2	physical	27432908
CNN3_HUMAN	CNN3	physical	27432908
MIPO1_HUMAN	MIPOL1	physical	27432908
ACTY_HUMAN	ACTR1B	physical	27432908
ARP10_HUMAN	ACTR10	physical	27432908
CCS_HUMAN	CCS	physical	27432908
DHRS4_HUMAN	DHRS4	physical	27432908
IF5A1_HUMAN	EIF5A	physical	27432908
NACC1_HUMAN	NACC1	physical	27432908
ACTZ_HUMAN	ACTR1A	physical	27432908
DOCK7_HUMAN	DOCK7	physical	27432908
CYBP_HUMAN	CACYBP	physical	27432908
KAD6_HUMAN	AK6	physical	27432908
EFGM_HUMAN	GFM1	physical	27432908
MTDC_HUMAN	MTHFD2	physical	27432908
DCTN4_HUMAN	DCTN4	physical	27432908
SPB6_HUMAN	SERPINB6	physical	27432908
THIO_HUMAN	TXN	physical	27432908
RL36_HUMAN	RPL36	physical	27432908
DUS3_HUMAN	DUSP3	physical	27432908
PDIA3_HUMAN	PDIA3	physical	27432908
PGAM1_HUMAN	PGAM1	physical	27432908
PDIA1_HUMAN	P4HB	physical	27432908
FKB10_HUMAN	FKBP10	physical	27432908
DNPEP_HUMAN	DNPEP	physical	27432908
PRDX6_HUMAN	PRDX6	physical	27432908
CSN8_HUMAN	COPS8	physical	27432908
CYTB_HUMAN	CSTB	physical	27432908
PRDX5_HUMAN	PRDX5	physical	27432908
ODO2_HUMAN	DLST	physical	27432908
PRDX3_HUMAN	PRDX3	physical	27432908
EXOS6_HUMAN	EXOSC6	physical	27432908
CALR_HUMAN	CALR	physical	27432908
HEM6_HUMAN	CPOX	physical	27432908
TXND5_HUMAN	TXNDC5	physical	27432908
GRB2_HUMAN	GRB2	physical	27432908
IPYR2_HUMAN	PPA2	physical	27432908
UBA5_HUMAN	UBA5	physical	27432908
SLD5_HUMAN	GINS4	physical	27432908
SDHB_HUMAN	SDHB	physical	27432908
SYWC_HUMAN	WARS	physical	27432908
OTUB1_HUMAN	OTUB1	physical	27432908
EXOS8_HUMAN	EXOSC8	physical	27432908
DUT_HUMAN	DUT	physical	27432908
ACLY_HUMAN	ACLY	physical	27432908
PDIA6_HUMAN	PDIA6	physical	27432908
GAPD1_HUMAN	GAPVD1	physical	27432908
PIMT_HUMAN	PCMT1	physical	27432908
AKT1_HUMAN	AKT1	physical	27432908

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DS13B_HUMAN

Related Literatures of Post-Translational Modification