PERM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PERM1_HUMAN
• UniProt AC: Q5SV97
• Protein Name: PGC-1 and ERR-induced regulator in muscle protein 1
• Gene Name: PERM1
• Organism: Homo sapiens (Human).
• Sequence Length: 790
• Subcellular Localization: Cytoplasm . Nucleus . Shows a nuclear localization in the presence of PPARGC1A.
• Protein Description: Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4..
• Protein Sequence: MENFQYSVQLSDQDWAEFSATADECGLLQAGLASGDELLSSDIDQGDSSGSSPPRAPPLPTGQLAAGGRSRRGCEEEDVATQQPVSRSQGEPVLALGTGQQTPSTSARAEAPPSLGPGASPPSQFSSCPGPASSGDQMQRLLQGPAPRPPGEPPGSPKSPGHSTGSQRPPDSPGAPPRSPSRKKRRAVGAKGGGHTGASASAQTGSPLLPAASPETAKLMAKAGQEELGPGPAGAPEPGPRSPVQEDRPGPGLGLSTPVPVTEQGTDQIRTPRRAKLHTVSTTVWEALPDVSRAKSDMAVSTPASEPQPDRDMAVSTPASEPQSDRDMAVSTPASEPQPDTDMAVSTPASEPQPDRDMAVSIPASKPQSDTAVSTPASEPQSSVALSTPISKPQLDTDVAVSTPASKHGLDVALPTAGPVAKLEVASSPPVSEAVPRMTESSGLVSTPVPRADAAGLAWPPTRRAGPDVVEMEAVVSEPSAGAPGCCSGAPALGLTQVPRKKKVRFSVAGPSPNKPGSGQASARPSAPQTATGAHGGPGAWEAVAVGPRPHQPRILKHLPRPPPSAVTRVGPGSSFAVTLPEAYEFFFCDTIEENEEAEAAAAGQDPAGVQWPDMCEFFFPDVGAQRSRRRGSPEPLPRADPVPAPIPGDPVPISIPEVYEHFFFGEDRLEGVLGPAVPLPLQALEPPRSASEGAGPGTPLKPAVVERLHLALRRAGELRGPVPSFAFSQNDMCLVFVAFATWAVRTSDPHTPDAWKTALLANVGTISAIRYFRRQVGQGRRSHSPSPSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
156	Phosphorylation	PPGEPPGSPKSPGHS CCCCCCCCCCCCCCC		19764811
159	Phosphorylation	EPPGSPKSPGHSTGS CCCCCCCCCCCCCCC		26437602
172	Phosphorylation	GSQRPPDSPGAPPRS CCCCCCCCCCCCCCC		26437602
179	Phosphorylation	SPGAPPRSPSRKKRR CCCCCCCCCCHHHCC		26437602
206	Phosphorylation	SASAQTGSPLLPAAS CCCCCCCCCCCCCCC		26437602
213	Phosphorylation	SPLLPAASPETAKLM CCCCCCCCHHHHHHH		26437602
242	Phosphorylation	APEPGPRSPVQEDRP CCCCCCCCCCCCCCC		26437602
427	Phosphorylation	VAKLEVASSPPVSEA EEEEEECCCCCHHHH		22673903
428	Phosphorylation	AKLEVASSPPVSEAV EEEEECCCCCHHHHC		26437602
432	Phosphorylation	VASSPPVSEAVPRMT ECCCCCHHHHCCCCC		22673903
446	Phosphorylation	TESSGLVSTPVPRAD CCCCCCCCCCCCCCC		28857561
447	Phosphorylation	ESSGLVSTPVPRADA CCCCCCCCCCCCCCC		26437602
633	Phosphorylation	QRSRRRGSPEPLPRA HHHHCCCCCCCCCCC		26437602
783	Phosphorylation	QVGQGRRSHSPSPSS HHCCCCCCCCCCCCC		26437602
785	Phosphorylation	GQGRRSHSPSPSS-- CCCCCCCCCCCCC--		26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PERM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PERM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PERM1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PERM1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.