MYPR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYPR_HUMAN
• UniProt AC: P60201
• Protein Name: Myelin proteolipid protein
• Gene Name: PLP1
• Organism: Homo sapiens (Human).
• Sequence Length: 277
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Myelin membrane. Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat..
• Protein Description: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin..
• Protein Sequence: MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	S-palmitoylation	--MGLLECCARCLVG --CCHHHHHHHHHCC	1.91	-
7	S-palmitoylation	-MGLLECCARCLVGA -CCHHHHHHHHHCCC	1.63	-
10	S-palmitoylation	LLECCARCLVGAPFA HHHHHHHHHCCCHHH	1.60	-
109	S-palmitoylation	GDYKTTICGKGLSAT CCCCEEEECCCEEEE	4.29	-
114	Phosphorylation	TICGKGLSATVTGGQ EEECCCEEEEECCCC	30.48	20886841
116	Phosphorylation	CGKGLSATVTGGQKG ECCCEEEEECCCCCC	18.41	20886841
118	Phosphorylation	KGLSATVTGGQKGRG CCEEEEECCCCCCCC	31.10	20886841
139	S-palmitoylation	AHSLERVCHCLGKWL HHHHHHHHHHHHHHC	2.05	-
141	S-palmitoylation	SLERVCHCLGKWLGH HHHHHHHHHHHHCCC	4.54	-
193	Phosphorylation	SIAFPSKTSASIGSL HHCCCCCCCCCHHHH	33.59	24076635
194	Phosphorylation	IAFPSKTSASIGSLC HCCCCCCCCCHHHHH	24.61	24076635
196	Phosphorylation	FPSKTSASIGSLCAD CCCCCCCCHHHHHHH	27.52	24076635
196	O-linked_Glycosylation	FPSKTSASIGSLCAD CCCCCCCCHHHHHHH	27.52	28657654
199	Phosphorylation	KTSASIGSLCADARM CCCCCHHHHHHHHHH	20.71	24076635
199	O-palmitoylation	KTSASIGSLCADARM CCCCCHHHHHHHHHH	20.71	-
207	Phosphorylation	LCADARMYGVLPWNA HHHHHHHHCCCCCCC	9.87	18083107
222	Phosphorylation	FPGKVCGSNLLSICK CCCCCCCCHHHHHHC	21.12	24076635
226	Phosphorylation	VCGSNLLSICKTAEF CCCCHHHHHHCCCHH	29.16	24076635

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYPR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYPR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYPR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTPRN_HUMAN	PTPRN	physical	25416956
ITB5_HUMAN	ITGB5	physical	12196561
ITAV_HUMAN	ITGAV	physical	12196561
CALR_HUMAN	CALR	physical	12196561
PTPRN_HUMAN	PTPRN	physical	21516116
REEP6_HUMAN	REEP6	physical	28514442
FGOP2_HUMAN	FGFR1OP2	physical	28514442
SLMAP_HUMAN	SLMAP	physical	28514442
REEP5_HUMAN	REEP5	physical	28514442
STRN_HUMAN	STRN	physical	28514442
SIKE1_HUMAN	SIKE1	physical	28514442
CD032_HUMAN	C4orf32	physical	28514442
RTN2_HUMAN	RTN2	physical	28514442
STRN4_HUMAN	STRN4	physical	28514442
GALD1_HUMAN	PDDC1	physical	28514442
STRP1_HUMAN	STRIP1	physical	28514442
RN114_HUMAN	RNF114	physical	28514442
RASN_HUMAN	NRAS	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00266: Hereditary spastic paraplegia (SPG)
• H00679: Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
• OMIM Disease
• 312080: Leukodystrophy, hypomyelinating, 1 (HLD1)
• 312920: Spastic paraplegia 2, X-linked (SPG2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.