dbPTM

AQP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AQP1_HUMAN
UniProt AC	P29972
Protein Name	Aquaporin-1
Gene Name	AQP1
Organism	Homo sapiens (Human).
Sequence Length	269
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient..
Protein Sequence	MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	N-linked_Glycosylation	FKYPVGNNQTAVQDN CCCCCCCCCCCCCCC	34.35	UniProtKB CARBOHYD
157	Phosphorylation	VLCVLATTDRRRRDL HHHHHHCCCHHHHHC	23.15	22817900
167	Phosphorylation	RRRDLGGSAPLAIGL HHHHCCCCCCHHHHH	25.55	25332170
175	Phosphorylation	APLAIGLSVALGHLL CCHHHHHHHHHHHHH	10.51	25332170
205	N-linked_Glycosylation	GSAVITHNFSNHWIF CCEEEEECCCCCEEE	33.13	UniProtKB CARBOHYD
236	O-linked_Glycosylation	FILAPRSSDLTDRVK HHHCCCCCCCCCCEE	37.61	12623621
236	Phosphorylation	FILAPRSSDLTDRVK HHHCCCCCCCCCCEE	37.61	-
239	Phosphorylation	APRSSDLTDRVKVWT CCCCCCCCCCEEEEC	27.10	28857561
246	Phosphorylation	TDRVKVWTSGQVEEY CCCEEEECCCCEEEE	26.43	23403867
247	Phosphorylation	DRVKVWTSGQVEEYD CCEEEECCCCEEEEE	16.12	26657352
253	Phosphorylation	TSGQVEEYDLDADDI CCCCEEEEECCHHHH	14.32	23403867
262	Phosphorylation	LDADDINSRVEMKPK CCHHHHHCCCCCCCC	37.73	19664994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
157	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
157	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
157	T	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
239	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
239	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
239	T	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AQP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AQP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDFI_HUMAN	MDFI	physical	16189514
FBLN4_HUMAN	EFEMP2	physical	16189514
KCD17_HUMAN	KCTD17	physical	16189514
KR412_HUMAN	KRTAP4-12	physical	16189514
TRIP6_HUMAN	TRIP6	physical	16189514
CC85B_HUMAN	CCDC85B	physical	16189514
MDFI_HUMAN	MDFI	physical	19447967
MDFI_HUMAN	MDFI	physical	19060904
ATL4_HUMAN	ADAMTSL4	physical	19060904
AQP1_HUMAN	AQP1	physical	25416956
TRI23_HUMAN	TRIM23	physical	25416956
FOS_HUMAN	FOS	physical	25416956
K1H1_HUMAN	KRT31	physical	25416956
KT33B_HUMAN	KRT33B	physical	25416956
SIAH1_HUMAN	SIAH1	physical	25416956
ITF2_HUMAN	TCF4	physical	25416956
TRAF1_HUMAN	TRAF1	physical	25416956
TRAF2_HUMAN	TRAF2	physical	25416956
TRIP6_HUMAN	TRIP6	physical	25416956
RGS20_HUMAN	RGS20	physical	25416956
ACK1_HUMAN	TNK2	physical	25416956
SPY2_HUMAN	SPRY2	physical	25416956
TRIM1_HUMAN	MID2	physical	25416956
IKZF3_HUMAN	IKZF3	physical	25416956
IKZF2_HUMAN	IKZF2	physical	25416956
MTUS2_HUMAN	MTUS2	physical	25416956
RGS17_HUMAN	RGS17	physical	25416956
KCTD9_HUMAN	KCTD9	physical	25416956
CRAC1_HUMAN	CRTAC1	physical	25416956
CSRN1_HUMAN	CSRNP1	physical	25416956
CC136_HUMAN	CCDC136	physical	25416956
CEP44_HUMAN	CEP44	physical	25416956
KRA92_HUMAN	KRTAP9-2	physical	25416956
KRA42_HUMAN	KRTAP4-2	physical	25416956
RIM3A_HUMAN	RIMBP3	physical	25416956
FSD2_HUMAN	FSD2	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
K1958_HUMAN	KIAA1958	physical	25416956
CCD57_HUMAN	CCDC57	physical	25416956
IHO1_HUMAN	CCDC36	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00819	Acetazolamide

Regulatory Network of AQP1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-262, AND MASSSPECTROMETRY.	18691976 [Abstract]