dbPTM

ADA33_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ADA33_HUMAN
UniProt AC	Q9BZ11
Protein Name	Disintegrin and metalloproteinase domain-containing protein 33
Gene Name	ADAM33
Organism	Homo sapiens (Human).
Sequence Length	813
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description
Protein Sequence	MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	N-linked_Glycosylation	QPVVLAPNHTDHCHY CEEEECCCCCCCCCC	45.12	UniProtKB CARBOHYD
145	N-linked_Glycosylation	GLITLSRNASYYLRP CEEEEECCCEEEECC	29.84	UniProtKB CARBOHYD
187	Methylation	GHRDPGNKAGMTSLP CCCCCCCCCCCCCCC	52.83	-
192	Phosphorylation	GNKAGMTSLPGGPQS CCCCCCCCCCCCCCC	24.55	28509920
231	N-linked_Glycosylation	LTRHRNLNHTKQRLL HHHCCCCCHHHHHHH	44.31	UniProtKB CARBOHYD
243	Phosphorylation	RLLEVANYVDQLLRT HHHHHHHHHHHHHHH	8.82	22817900
269	Phosphorylation	VWTERDRSRVTQDAN EECHHHHHHHCCHHH	35.08	17081983
276	N-linked_Glycosylation	SRVTQDANATLWAFL HHHCCHHHHHHHHHH	41.57	UniProtKB CARBOHYD
448	N-linked_Glycosylation	DLCCFAHNCSLRPGA HHHHHCCCCCCCCCC	17.40	UniProtKB CARBOHYD
489	Phosphorylation	CDLPEFCTGTSSHCP CCCCHHHCCCCCCCC	49.14	68707401
746	Phosphorylation	CRRDPACSGPKDGPH CCCCCCCCCCCCCCC	61.30	50563475

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ADA33_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ADA33_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ADA33_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASB7_HUMAN	ASB7	physical	28514442
ZDHC6_HUMAN	ZDHHC6	physical	28514442
HMOX1_HUMAN	HMOX1	physical	28514442
SOAT1_HUMAN	SOAT1	physical	28514442
TM39B_HUMAN	TMEM39B	physical	28514442
DYR2_HUMAN	DHFRL1	physical	28514442
S27A3_HUMAN	SLC27A3	physical	28514442
NOTC3_HUMAN	NOTCH3	physical	28514442
MKS3_HUMAN	TMEM67	physical	28514442
EGFL7_HUMAN	EGFL7	physical	28514442
1A02_HUMAN	HLA-A	physical	28514442
1A03_HUMAN	HLA-A	physical	28514442
1A01_HUMAN	HLA-A	physical	28514442
1A26_HUMAN	HLA-A	physical	28514442
TTC17_HUMAN	TTC17	physical	28514442
ITB5_HUMAN	ITGB5	physical	28514442
LRP12_HUMAN	LRP12	physical	28514442
FBX2_HUMAN	FBXO2	physical	28514442
1C07_HUMAN	HLA-C	physical	28514442
BI1_HUMAN	TMBIM6	physical	28514442
MANEL_HUMAN	MANEAL	physical	28514442
TOR3A_HUMAN	TOR3A	physical	28514442
IDD_HUMAN	DGCR2	physical	28514442
LSR_HUMAN	LSR	physical	28514442
FSTL1_HUMAN	FSTL1	physical	28514442
SDF2L_HUMAN	SDF2L1	physical	28514442
CISD3_HUMAN	CISD3	physical	28514442
LRP6_HUMAN	LRP6	physical	28514442
GLT12_HUMAN	GALNT12	physical	28514442
AMGO1_HUMAN	AMIGO1	physical	28514442
LRP5_HUMAN	LRP5	physical	28514442
CSTN1_HUMAN	CLSTN1	physical	28514442
TYW1_HUMAN	TYW1	physical	28514442
KCNJ8_HUMAN	KCNJ8	physical	28514442
ANR46_HUMAN	ANKRD46	physical	28514442
SEM4F_HUMAN	SEMA4F	physical	28514442
ADA15_HUMAN	ADAM15	physical	28514442
DEFM_HUMAN	PDF	physical	28514442
NETO2_HUMAN	NETO2	physical	28514442

Drug and Disease Associations

Kegg Disease
H00079	Asthma
OMIM Disease
600807	Asthma (ASTHMA)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ADA33_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, AND MASSSPECTROMETRY.	17081983 [Abstract]