GPR25_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPR25_HUMAN
• UniProt AC: O00155
• Protein Name: Probable G-protein coupled receptor 25
• Gene Name: GPR25
• Organism: Homo sapiens (Human).
• Sequence Length: 361
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Orphan receptor..
• Protein Sequence: MAPTEPWSPSPGSAPWDYSGLDGLEELELCPAGDLPYGYVYIPALYLAAFAVGLLGNAFVVWLLAGRRGPRRLVDTFVLHLAAADLGFVLTLPLWAAAAALGGRWPFGDGLCKLSSFALAGTRCAGALLLAGMSVDRYLAVVKLLEARPLRTPRCALASCCGVWAVALLAGLPSLVYRGLQPLPGGQDSQCGEEPSHAFQGLSLLLLLLTFVLPLVVTLFCYCRISRRLRRPPHVGRARRNSLRIIFAIESTFVGSWLPFSALRAVFHLARLGALPLPCPLLLALRWGLTIATCLAFVNSCANPLIYLLLDRSFRARALDGACGRTGRLARRISSASSLSRDDSSVFRCRAQAANTASASW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
115	Phosphorylation	GDGLCKLSSFALAGT CCCHHHHHHHHHCCC	14.65	23909892
116	Phosphorylation	DGLCKLSSFALAGTR CCHHHHHHHHHCCCH	25.60	23909892
122	Phosphorylation	SSFALAGTRCAGALL HHHHHCCCHHHHHHH	19.57	23909892
152	Phosphorylation	LEARPLRTPRCALAS HHCCCCCCCCHHHHH	23.83	24719451
159	Phosphorylation	TPRCALASCCGVWAV CCCHHHHHHHHHHHH	15.70	24667141
174	Phosphorylation	ALLAGLPSLVYRGLQ HHHCCCCHHHHCCCC	35.19	24667141
177	Phosphorylation	AGLPSLVYRGLQPLP CCCCHHHHCCCCCCC	12.31	24719451
256	Phosphorylation	IESTFVGSWLPFSAL EECCCCCCCCCHHHH	21.82	-
334	Phosphorylation	GRLARRISSASSLSR HHHHHHHHCCCCCCC	20.31	24719451
335	Phosphorylation	RLARRISSASSLSRD HHHHHHHCCCCCCCC	29.78	23312004
337	Phosphorylation	ARRISSASSLSRDDS HHHHHCCCCCCCCCC	33.49	26699800
338	Phosphorylation	RRISSASSLSRDDSS HHHHCCCCCCCCCCC	30.04	26699800
340	Phosphorylation	ISSASSLSRDDSSVF HHCCCCCCCCCCCHH	35.29	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPR25_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPR25_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPR25_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VAPB_HUMAN	VAPB	physical	25416956
PNMA1_HUMAN	PNMA1	physical	25416956
FATE1_HUMAN	FATE1	physical	25416956
CR3L1_HUMAN	CREB3L1	physical	25416956
KASH5_HUMAN	CCDC155	physical	25416956
NADL2_HUMAN	NAALADL2	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.