dbPTM

TNMD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TNMD_HUMAN
UniProt AC	Q9H2S6
Protein Name	Tenomodulin
Gene Name	TNMD
Organism	Homo sapiens (Human).
Sequence Length	317
Subcellular Localization	Isoform 1: Membrane Single-pass type II membrane protein . Nucleus envelope. Isoform 2: Membrane Single-pass type II membrane protein . Nucleus envelope. Isoform 3: Cytoplasm.
Protein Description	May be an angiogenesis inhibitor..
Protein Sequence	MAKNPPENCEDCHILNAEAFKSKKICKSLKICGLVFGILALTLIVLFWGSKHFWPEVPKKAYDMEHTFYSNGEKKKIYMEIDPVTRTEIFRSGNGTDETLEVHDFKNGYTGIYFVGLQKCFIKTQIKVIPEFSEPEEEIDENEEITTTFFEQSVIWVPAEKPIENRDFLKNSKILEICDNVTMYWINPTLISVSELQDFEEEGEDLHFPANEKKGIEQNEQWVVPQVKVEKTRHARQASEEELPINDYTENGIEFDPMLDERGYCCIYCRRGNRYCRRVCEPLLGYYPYPYCYQGGRVICRVIMPCNWWVARMLGRV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Acetylation	AEAFKSKKICKSLKI HHHHCCHHHHHHHHH	61.50	7297979
85	Phosphorylation	YMEIDPVTRTEIFRS EEEECCCCCEEEEEC	36.94	22210691
87	Phosphorylation	EIDPVTRTEIFRSGN EECCCCCEEEEECCC	24.86	22210691
94	N-linked_Glycosylation	TEIFRSGNGTDETLE EEEEECCCCCCCEEE	51.98	UniProtKB CARBOHYD
99	Phosphorylation	SGNGTDETLEVHDFK CCCCCCCEEEEEECC	30.91	22210691
180	N-linked_Glycosylation	KILEICDNVTMYWIN CHHHCCCCEEEEEEC	27.09	UniProtKB CARBOHYD
239	Phosphorylation	TRHARQASEEELPIN CCHHHHCCCCCCCCC	36.88	-
286	Phosphorylation	VCEPLLGYYPYPYCY HHHHHHCCCCCCCEE	10.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TNMD_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TNMD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TNMD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TMM79_HUMAN	TMEM79	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TNMD_HUMAN

Related Literatures of Post-Translational Modification