| UniProt ID | AGRE2_HUMAN | |
|---|---|---|
| UniProt AC | Q9UHX3 | |
| Protein Name | Adhesion G protein-coupled receptor E2 {ECO:0000303|PubMed:25713288} | |
| Gene Name | ADGRE2 {ECO:0000312|HGNC:HGNC:3337} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 823 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. Cell projection, ruffle membrane Multi-pass membrane protein. Localized at the leading edge of migrating cells. |
|
| Protein Description | Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation. [PubMed: 26841242] | |
| Protein Sequence | MGGRVFLVFLAFCVWLTLPGAETQDSRGCARWCPQDSSCVNATACRCNPGFSSFSEIITTPMETCDDINECATLSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKLKPEDPKLCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDYKPGLANNTIQSILQALDELLEAPGDLETLPRLQQHCVASHLLDGLEDVLRGLSKNLSNGLLNFSYPAGTELSLEVQKQVDRSVTLRQNQAVMQLDWNQAQKSGDPGPSVVGLVSIPGMGKLLAEAPLVLEPEKQMLLHETHQGLLQDGSPILLSDVISAFLSNNDTQNLSSPVTFTFSHRSVIPRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCTHLSSFAVLMAHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAHLLFLVAIDQTGHKVLCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVVNYSSINRFMKKLMFPVGYGVPAVTVAISAASRPHLYGTPSRCWLQPEKGFIWGFLGPVCAIFSVNLVLFLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQVGPAARVMAYLFTIINSLQGVFIFLVYCLLSQQVREQYGKWSKGIRKLKTESEMHTLSSSAKADTSKPSTVN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 41 | N-linked_Glycosylation | PQDSSCVNATACRCN CCCCCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 111 | N-linked_Glycosylation | SGAKTFKNESENTCQ CCCCCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 206 | N-linked_Glycosylation | PGSPNGPNNTVCEDV CCCCCCCCCCEECCH | UniProtKB CARBOHYD | ||
| 263 | Phosphorylation | DTVCEDMTFSTWTPP CCCCCCCCCCCCCCC | 22210691 | ||
| 275 | Phosphorylation | TPPPGVHSQTLSRFF CCCCCCCHHHHHHHH | 22210691 | ||
| 277 | Phosphorylation | PPGVHSQTLSRFFDK CCCCCHHHHHHHHHH | 22210691 | ||
| 284 | Ubiquitination | TLSRFFDKVQDLGRD HHHHHHHHHHHCCCC | - | ||
| 298 | N-linked_Glycosylation | DYKPGLANNTIQSIL CCCCCCCHHHHHHHH | UniProtKB CARBOHYD | ||
| 303 | Phosphorylation | LANNTIQSILQALDE CCHHHHHHHHHHHHH | - | ||
| 347 | N-linked_Glycosylation | VLRGLSKNLSNGLLN HHHHHHHHCCCCCCC | UniProtKB CARBOHYD | ||
| 354 | N-linked_Glycosylation | NLSNGLLNFSYPAGT HCCCCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 361 | O-linked_Glycosylation | NFSYPAGTELSLEVQ CCCCCCCCCEEHHHH | 29351928 | ||
| 364 | O-linked_Glycosylation | YPAGTELSLEVQKQV CCCCCCEEHHHHHHH | 29351928 | ||
| 376 | Phosphorylation | KQVDRSVTLRQNQAV HHHCCCEEHHHCCEE | 24719451 | ||
| 456 | N-linked_Glycosylation | ISAFLSNNDTQNLSS HHHHHCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 460 | N-linked_Glycosylation | LSNNDTQNLSSPVTF HCCCCCCCCCCCEEE | UniProtKB CARBOHYD | ||
| 636 | Phosphorylation | RNLTVVNYSSINRFM CCCEEECHHHHHHHH | 29978859 | ||
| 637 | Phosphorylation | NLTVVNYSSINRFMK CCEEECHHHHHHHHH | 29978859 | ||
| 638 | Phosphorylation | LTVVNYSSINRFMKK CEEECHHHHHHHHHH | 29978859 | ||
| 652 | Phosphorylation | KLMFPVGYGVPAVTV HHCCCCCCCCCHHHH | 25072903 | ||
| 658 | Phosphorylation | GYGVPAVTVAISAAS CCCCCHHHHHHHHCC | 25072903 | ||
| 662 | Phosphorylation | PAVTVAISAASRPHL CHHHHHHHHCCCCCC | 25072903 | ||
| 665 | Phosphorylation | TVAISAASRPHLYGT HHHHHHCCCCCCCCC | 25072903 | ||
| 670 | Phosphorylation | AASRPHLYGTPSRCW HCCCCCCCCCCCCCE | - | ||
| 672 | Phosphorylation | SRPHLYGTPSRCWLQ CCCCCCCCCCCCEEC | - | ||
| 674 | Phosphorylation | PHLYGTPSRCWLQPE CCCCCCCCCCEECCC | - | ||
| 801 | Phosphorylation | KGIRKLKTESEMHTL HHHHHCCCHHHHHHH | 25404012 | ||
| 803 | Phosphorylation | IRKLKTESEMHTLSS HHHCCCHHHHHHHHC | 25404012 | ||
| 807 | Phosphorylation | KTESEMHTLSSSAKA CCHHHHHHHHCCCCC | 25404012 | ||
| 809 | Phosphorylation | ESEMHTLSSSAKADT HHHHHHHHCCCCCCC | 25404012 | ||
| 810 | Phosphorylation | SEMHTLSSSAKADTS HHHHHHHCCCCCCCC | 24247654 | ||
| 811 | Phosphorylation | EMHTLSSSAKADTSK HHHHHHCCCCCCCCC | 24247654 | ||
| 813 | Ubiquitination | HTLSSSAKADTSKPS HHHHCCCCCCCCCCC | 21906983 | ||
| 816 | Phosphorylation | SSSAKADTSKPSTVN HCCCCCCCCCCCCCC | 25404012 | ||
| 817 | Phosphorylation | SSAKADTSKPSTVN- CCCCCCCCCCCCCC- | 25404012 | ||
| 818 | Ubiquitination | SAKADTSKPSTVN-- CCCCCCCCCCCCC-- | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AGRE2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AGRE2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AGRE2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of AGRE2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
