S13A3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S13A3_HUMAN
• UniProt AC: Q8WWT9
• Protein Name: Solute carrier family 13 member 3
• Gene Name: SLC13A3
• Organism: Homo sapiens (Human).
• Sequence Length: 602
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate..
• Protein Sequence: MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETEPLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTALPPTLANDTFRTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Acetylation	AALAAAAKKVWSARR HHHHHHHHHHHHHHH	43.03	7668763
51	Phosphorylation	VILLMAVYWCTEALP HHHHHHHHHHHCCCC	5.80	25072903
54	Phosphorylation	LMAVYWCTEALPLSV HHHHHHHHCCCCCCH	15.33	25072903
60	Phosphorylation	CTEALPLSVTALLPI HHCCCCCCHHHHHHH	18.58	25072903
62	Phosphorylation	EALPLSVTALLPIVL CCCCCCHHHHHHHHH	14.28	25072903
78	Phosphorylation	PFMGILPSNKVCPQY HHCCCCCCCCCCCHH	45.93	25072903
173	Phosphorylation	KEVRKDPSQESEENT HHHCCCCCCCCHHHH	57.63	28857561
176	Phosphorylation	RKDPSQESEENTAAV CCCCCCCCHHHHHHH	42.44	28857561
180	Phosphorylation	SQESEENTAAVRRNG CCCCHHHHHHHHHCC	21.19	30242111
190	Phosphorylation	VRRNGLHTVPTEMQF HHHCCCCCCCCHHHH	32.97	28857561
193	Phosphorylation	NGLHTVPTEMQFLAS CCCCCCCCHHHHHHC	39.49	28857561
207 (in isoform 5)	Phosphorylation	-	53.07	24114839
207 (in isoform 4)	Phosphorylation	-	53.07	24114839
208 (in isoform 5)	Phosphorylation	-	51.55	24114839
208 (in isoform 4)	Phosphorylation	-	51.55	24114839
212 (in isoform 5)	Phosphorylation	-	8.13	24114839
212 (in isoform 4)	Phosphorylation	-	8.13	24114839
218 (in isoform 5)	Phosphorylation	-	34.41	24114839
218 (in isoform 4)	Phosphorylation	-	34.41	24114839
226	Phosphorylation	DSRKEDEYRRNIWKG CCCCHHHHHHHCCCC	27.48	-
241 (in isoform 4)	Phosphorylation	-	15.36	22210691
241 (in isoform 5)	Phosphorylation	-	15.36	22210691
410	Phosphorylation	FDFKAPNTETEPLLT EEECCCCCCCCCCCC	43.13	-
412	Phosphorylation	FKAPNTETEPLLTWK ECCCCCCCCCCCCHH	40.64	-
586	N-linked_Glycosylation	WADMYSVNVTALPPT HHHHCEEEEEECCCC	21.34	UniProtKB CARBOHYD
593	O-linked_Glycosylation	NVTALPPTLANDTFR EEEECCCCCCCCCCC	36.24	OGP
596	N-linked_Glycosylation	ALPPTLANDTFRTL- ECCCCCCCCCCCCC-	52.55	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S13A3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S13A3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S13A3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of S13A3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.