MLIP_HUMAN - dbPTM
MLIP_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MLIP_HUMAN
UniProt AC Q5VWP3
Protein Name Muscular LMNA-interacting protein {ECO:0000312|HGNC:HGNC:21355}
Gene Name MLIP {ECO:0000312|HGNC:HGNC:21355}
Organism Homo sapiens (Human).
Sequence Length 458
Subcellular Localization Nucleus . Nucleus envelope . Nucleus, PML body . Cell membrane, sarcolemma
Peripheral membrane protein
Cytoplasmic side .
Protein Description Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD..
Protein Sequence MELEKREKRSLLNKNLEEKLTVSAGGSEAKPLIFTFVPTVRRLPTHTQLADTSKFLVKIPEESSDKSPETVNRSKSNDYLTLNAGSQQERDQAKLTCPSEVSGTILQEREFEANKLQGMQQSDLFKAEYVLIVDSEGEDEAASRKVEQGPPGGIGTAAVRPKSLAISSSLVSDVVRPKTQGTDLKTSSHPEMLHGMAPQQKHGQQYKTKSSYKAFAAIPTNTLLLEQKALDEPAKTESVSKDNTLEPPVELYFPAQLRQQTEELCATIDKVLQDSLSMHSSDSPSRSPKTLLGSDTVKTPTTLPRAAGRETKYANLSSPSSTVSESQLTKPGVIRPVPVKSRILLKKEEEVYEPNPFSKYLEDNSDLFSEQDVTVPPKPVSLHPLYQTKLYPPAKSLLHPQTLSHADCLAPGPFSHLSFSLSDEQENSHTLLSHNACNKLSHPMVAIPEHEALDSKEQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationLEKREKRSLLNKNLE
HHHHHHHHHHCCCHH		48.5624719451
45PhosphorylationPTVRRLPTHTQLADT
CCCCCCCCCCCCCCC		41.99-
47PhosphorylationVRRLPTHTQLADTSK
CCCCCCCCCCCCCCC		27.96-
63PhosphorylationLVKIPEESSDKSPET
EEECCHHHCCCCCCC		42.0222673903
64PhosphorylationVKIPEESSDKSPETV
EECCHHHCCCCCCCC		52.9529209046
67PhosphorylationPEESSDKSPETVNRS
CHHHCCCCCCCCCCH		32.7226657352
70PhosphorylationSSDKSPETVNRSKSN
HCCCCCCCCCCHHCC		26.8522673903
74PhosphorylationSPETVNRSKSNDYLT
CCCCCCCHHCCCCEE		34.9226437602
76PhosphorylationETVNRSKSNDYLTLN
CCCCCHHCCCCEEEC		35.8626437602
86PhosphorylationYLTLNAGSQQERDQA
CEEECCCCHHHHHHH		26.7025159151
135PhosphorylationEYVLIVDSEGEDEAA
EEEEEECCCCCCHHH		36.2929255136
143PhosphorylationEGEDEAASRKVEQGP
CCCCHHHHCCHHCCC		39.4222673903
163PhosphorylationTAAVRPKSLAISSSL
CCCCCCHHEEEEHHH		26.2226437602
167PhosphorylationRPKSLAISSSLVSDV
CCHHEEEEHHHHHCC		14.3122210691
168PhosphorylationPKSLAISSSLVSDVV
CHHEEEEHHHHHCCC		22.9022210691
169PhosphorylationKSLAISSSLVSDVVR
HHEEEEHHHHHCCCC		26.4626437602
172PhosphorylationAISSSLVSDVVRPKT
EEEHHHHHCCCCCCC		29.9522210691
236O-linked_GlycosylationALDEPAKTESVSKDN
HHCCCCCCCCCCCCC		35.2828657654
238PhosphorylationDEPAKTESVSKDNTL
CCCCCCCCCCCCCCC		36.6024719451
261PhosphorylationPAQLRQQTEELCATI
CHHHHHHHHHHHHHH		24.0826437602
277PhosphorylationKVLQDSLSMHSSDSP
HHHHHHHHCCCCCCC		20.5726437602
283PhosphorylationLSMHSSDSPSRSPKT
HHCCCCCCCCCCCCC		27.0726437602
287PhosphorylationSSDSPSRSPKTLLGS
CCCCCCCCCCCCCCC		34.7826437602
290PhosphorylationSPSRSPKTLLGSDTV
CCCCCCCCCCCCCCC		30.5126437602
296PhosphorylationKTLLGSDTVKTPTTL
CCCCCCCCCCCCCCC		26.12-
299PhosphorylationLGSDTVKTPTTLPRA
CCCCCCCCCCCCCCC		22.8726437602
301PhosphorylationSDTVKTPTTLPRAAG
CCCCCCCCCCCCCCC		46.31-
302PhosphorylationDTVKTPTTLPRAAGR
CCCCCCCCCCCCCCC		35.6526437602
311PhosphorylationPRAAGRETKYANLSS
CCCCCCCCCCCCCCC		28.17-
313PhosphorylationAAGRETKYANLSSPS
CCCCCCCCCCCCCCC		14.2426270265
317PhosphorylationETKYANLSSPSSTVS
CCCCCCCCCCCCCCC		39.7626270265
318PhosphorylationTKYANLSSPSSTVSE
CCCCCCCCCCCCCCH		31.7826270265
319 (in isoform 4)Phosphorylation-28.9926437602
320PhosphorylationYANLSSPSSTVSESQ
CCCCCCCCCCCCHHH		40.3626270265
321PhosphorylationANLSSPSSTVSESQL
CCCCCCCCCCCHHHC		35.8926270265
322PhosphorylationNLSSPSSTVSESQLT
CCCCCCCCCCHHHCC		32.1826270265
324PhosphorylationSSPSSTVSESQLTKP
CCCCCCCCHHHCCCC		31.4526270265
326PhosphorylationPSSTVSESQLTKPGV
CCCCCCHHHCCCCCE		24.0026270265
327 (in isoform 4)Phosphorylation-49.4526437602
329PhosphorylationTVSESQLTKPGVIRP
CCCHHHCCCCCEEEC		27.7926270265
330 (in isoform 3)Phosphorylation-48.6526437602
331 (in isoform 4)Phosphorylation-36.7326437602
334 (in isoform 4)Phosphorylation-5.2326437602
337 (in isoform 4)Phosphorylation-6.4626437602
338 (in isoform 3)Phosphorylation-30.4226437602
342 (in isoform 3)Phosphorylation-20.1826437602
345 (in isoform 3)Phosphorylation-7.4826437602
347 (in isoform 4)Phosphorylation-71.0326437602
348 (in isoform 3)Phosphorylation-58.7826437602
349 (in isoform 4)Phosphorylation-62.7426437602
352PhosphorylationLKKEEEVYEPNPFSK
EECCHHCCCCCCHHH		29.02-
358 (in isoform 3)Phosphorylation-22.9626437602
360 (in isoform 3)Phosphorylation-17.7126437602
370 (in isoform 4)Phosphorylation-43.3924043423
371 (in isoform 4)Phosphorylation-49.6424043423
372 (in isoform 4)Phosphorylation-33.7224043423
376 (in isoform 4)Phosphorylation-23.1024043423
377 (in isoform 4)Phosphorylation-49.6124043423
378 (in isoform 4)Phosphorylation-52.5624043423
379 (in isoform 4)Phosphorylation-27.0624043423
381 (in isoform 3)Phosphorylation-29.5024043423
382 (in isoform 3)Phosphorylation-4.9924043423
382 (in isoform 4)Phosphorylation-4.9924043423
383 (in isoform 3)Phosphorylation-11.6524043423
385 (in isoform 4)Phosphorylation-3.2624043423
386 (in isoform 4)Phosphorylation-20.7024043423
387 (in isoform 3)Phosphorylation-39.5824043423
387 (in isoform 4)Phosphorylation-39.5824043423
388 (in isoform 3)Phosphorylation-14.9524043423
389 (in isoform 3)Phosphorylation-30.4224043423
390 (in isoform 3)Phosphorylation-9.8424043423
391 (in isoform 4)Phosphorylation-14.5524043423
393 (in isoform 3)Phosphorylation-38.4724043423
393 (in isoform 4)Phosphorylation-38.4726437602
396 (in isoform 3)Phosphorylation-37.9724043423
397 (in isoform 3)Phosphorylation-5.1224043423
397 (in isoform 4)Phosphorylation-5.1226437602
398 (in isoform 3)Phosphorylation-7.7524043423
401 (in isoform 4)Phosphorylation-44.3019764811
402 (in isoform 3)Phosphorylation-34.3824043423
404 (in isoform 3)Phosphorylation-21.7326437602
408 (in isoform 3)Phosphorylation-3.4726437602
412 (in isoform 3)Phosphorylation-30.2219764811
412 (in isoform 4)Phosphorylation-30.2226437602
421 (in isoform 4)Phosphorylation-7.6326437602
423 (in isoform 3)Phosphorylation-67.8826437602
429 (in isoform 4)Phosphorylation-31.9225850435
432 (in isoform 3)Phosphorylation-5.2826437602
432 (in isoform 4)Phosphorylation-5.2826437602
435 (in isoform 4)Phosphorylation-42.6925850435
440 (in isoform 3)Phosphorylation-3.3725850435
443 (in isoform 3)Phosphorylation-18.6326437602
446 (in isoform 3)Phosphorylation-12.8425850435
447 (in isoform 4)Phosphorylation-2.5326437602
450 (in isoform 4)Phosphorylation-21.9226437602
454 (in isoform 4)Phosphorylation-65.7926437602
456 (in isoform 4)Phosphorylation-60.8526437602
458 (in isoform 3)Phosphorylation-63.4526437602
459 (in isoform 4)Phosphorylation-26437602
461 (in isoform 3)Phosphorylation-26437602
464 (in isoform 4)Phosphorylation-25850435
465 (in isoform 3)Phosphorylation-26437602
467 (in isoform 3)Phosphorylation-26437602
470 (in isoform 3)Phosphorylation-26437602
475 (in isoform 3)Phosphorylation-25850435
488 (in isoform 4)Phosphorylation-26437602
496 (in isoform 4)Phosphorylation-22673903
498 (in isoform 4)Phosphorylation-26437602
499 (in isoform 3)Phosphorylation-26437602
500 (in isoform 4)Phosphorylation-22673903
505 (in isoform 4)Phosphorylation-22210691
507 (in isoform 3)Phosphorylation-22673903
509 (in isoform 3)Phosphorylation-26437602
509 (in isoform 4)Phosphorylation-26437602
511 (in isoform 3)Phosphorylation-22673903
515 (in isoform 4)Phosphorylation-26437602
516 (in isoform 3)Phosphorylation-22210691
517 (in isoform 4)Phosphorylation-26055452
519 (in isoform 4)Phosphorylation-27732954
520 (in isoform 3)Phosphorylation-26437602
526 (in isoform 3)Phosphorylation-26437602
528 (in isoform 3)Phosphorylation-26055452
530 (in isoform 3)Phosphorylation-27732954
584 (in isoform 4)Phosphorylation-26437602
592 (in isoform 4)Phosphorylation-26437602
595 (in isoform 3)Phosphorylation-26437602
595 (in isoform 4)Phosphorylation-26437602
596 (in isoform 4)Phosphorylation-26437602
603 (in isoform 3)Phosphorylation-26437602
606 (in isoform 3)Phosphorylation-26437602
607 (in isoform 3)Phosphorylation-26437602
648 (in isoform 4)Phosphorylation-26437602
659 (in isoform 3)Phosphorylation-26437602
664 (in isoform 4)Phosphorylation-26437602
674 (in isoform 4)Phosphorylation-26437602
675 (in isoform 3)Phosphorylation-26437602
684 (in isoform 4)Phosphorylation-26437602
685 (in isoform 3)Phosphorylation-26437602
693 (in isoform 4)Phosphorylation-26437602
695 (in isoform 3)Phosphorylation-26437602
704 (in isoform 3)Phosphorylation-26437602
705 (in isoform 4)Phosphorylation-22210691
707 (in isoform 4)Phosphorylation-22210691
716 (in isoform 3)Phosphorylation-22210691
718 (in isoform 3)Phosphorylation-22210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MLIP_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MLIP_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MLIP_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LMNA_HUMANLMNAphysical
21498514
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MLIP_HUMAN

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Related Literatures of Post-Translational Modification

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