NINJ2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NINJ2_HUMAN
• UniProt AC: Q9NZG7
• Protein Name: Ninjurin-2
• Gene Name: NINJ2
• Organism: Homo sapiens (Human).
• Sequence Length: 142
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues..
• Protein Sequence: MESARENIDLQPGSSDPRSQPINLNHYATKKSVAESMLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFGAHKTGFLAARASRNPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESARENIDL -----CCCHHHHCCC	31.18	17081983
14	Phosphorylation	NIDLQPGSSDPRSQP HCCCCCCCCCCCCCC	37.95	30001349
15	Phosphorylation	IDLQPGSSDPRSQPI CCCCCCCCCCCCCCC	58.51	30001349
19	Phosphorylation	PGSSDPRSQPINLNH CCCCCCCCCCCCCCH	45.77	-
29	Phosphorylation	INLNHYATKKSVAES CCCCHHCCHHHHHHH	31.66	-
49	Phosphorylation	LFMSNAMRLKAVLEQ HHHHHHHHHHHHHHH	30.53	17081983
130	Phosphorylation	TAFGAHKTGFLAARA HHHCHHHHHHHHHHH	24.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NINJ2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NINJ2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NINJ2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NINJ2_HUMAN	NINJ2	physical	25416956
B2L13_HUMAN	BCL2L13	physical	25416956
CLC7A_HUMAN	CLEC7A	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3, AND MASSSPECTROMETRY.
PubMed: 17081983