TBL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBL2_MOUSE
• UniProt AC: Q9R099
• Protein Name: Transducin beta-like protein 2
• Gene Name: Tbl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 442
• Protein Sequence: MELPQMPELMGLSLLVGLLALVATAAVARGWLRAEEKPSQPVCQKENEPKKSGSKKQKQNQRVRKEKPQQHSFTHPLLAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKDFLQREHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGFTFTATPEDFPKKHKAPIINIGIADTGKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDVKVWEVCFGKKGEFQEVLRAFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKQQDPYLLRTGRFEEASTMPCRLALSPDTHVLALATGTNIHLFNTRRGEKEEYFECVHGECIADLTFDITGRFLASCGDRAVRLFHNTPGHRAVVEEMQSLLKRASSESTRQRLQQQLTQAQEALKSLGALKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	KSHSGNISCMDFSSN HHCCCCEEEEECCCC	13.85	29514104
116	Ubiquitination	TVRIWSTKDFLQREH EEEEEEHHHHHHHHH	40.75	-
116	Acetylation	TVRIWSTKDFLQREH EEEEEEHHHHHHHHH	40.75	23201123
116	Malonylation	TVRIWSTKDFLQREH EEEEEEHHHHHHHHH	40.75	26320211
236	S-palmitoylation	SHAVISPCSRFVGSC CEEEEECCHHHHHCC	3.49	28526873
243	S-palmitoylation	CSRFVGSCGFTPDVK CHHHHHCCCCCCCCE	4.23	28526873
259	Malonylation	WEVCFGKKGEFQEVL EEEECCCCCCHHHHH	65.14	26320211
310	Ubiquitination	DTDVEYKKQQDPYLL CCCCHHHHCCCCCEE	52.90	22790023
330	S-palmitoylation	EEASTMPCRLALSPD CCCCCCCEEEEECCC	3.75	28526873
409	Phosphorylation	AVVEEMQSLLKRASS HHHHHHHHHHHHHCC	34.07	28066266
412	Ubiquitination	EEMQSLLKRASSEST HHHHHHHHHHCCHHH	51.73	-
412	Malonylation	EEMQSLLKRASSEST HHHHHHHHHHCCHHH	51.73	26320211
415	Phosphorylation	QSLLKRASSESTRQR HHHHHHHCCHHHHHH	38.38	23140645
416	Phosphorylation	SLLKRASSESTRQRL HHHHHHCCHHHHHHH	34.28	23140645
428	Phosphorylation	QRLQQQLTQAQEALK HHHHHHHHHHHHHHH	19.95	-
435	Ubiquitination	TQAQEALKSLGALKK HHHHHHHHHCCCCCC	51.16	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBL2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBL2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TBL2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.