RTKN_MOUSE - dbPTM
RTKN_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RTKN_MOUSE
UniProt AC Q8C6B2
Protein Name Rhotekin
Gene Name Rtkn {ECO:0000312|MGI:MGI:107371}
Organism Mus musculus (Mouse).
Sequence Length 564
Subcellular Localization
Protein Description Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures (By similarity)..
Protein Sequence MFSRNHRSRITVARGSALEMEFKRGRFRLSFFSESPEDTELQRKLDHEIRMRDGACKLLAACSQREQALEATKSLLVCNSRILSYMGELQRRKEAQVLEKTGRRPSDSVQPAQHSPCRGRVCISDLRIPLMWKDTEYFKNKGDLHRWAVFLLLQIGEQIQDTEMVLVDRTLTDISFQNNVLFAEAEPDFELRLELYGACVEEEGALAGAPKRLATKLSSSLGRSSGKRVRASLDSAGASGNSPVLLPTPAVGGPRFHLLAHTTLTLEEVQDGFRTHDLTLTSHEENPAWLPLYGSVCCRLAAQPLCMIQPTASGALRVQQAGELQNGTLVHGVLKGTNLFCYWRSEDADTGQEPLFTIVINKETRVRAGELEQAPEWPFTLSISNKYGDDEVTNTLQLESREALQNWMEALWQLFFDMSQWRHCCDEVMKIETPAPRKPPQALAKQGSLYHEMAIEPLDDIAAVTDILAQREGTRLEPSPPWLAMFTDQPALPSSCSPASVAPVPTWMQPLPWGRPRTFSLDAAPADHSLGPSRSVAPLPPQRSPKSRGFYSKSQLGPWLQSPV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14MethylationRSRITVARGSALEME
HHCEEEEECCCEEEE		34.9512229231
30PhosphorylationKRGRFRLSFFSESPE
CCCCEEEEEECCCCC		21.7126239621
33PhosphorylationRFRLSFFSESPEDTE
CEEEEEECCCCCCHH		34.8423984901
35PhosphorylationRLSFFSESPEDTELQ
EEEEECCCCCCHHHH		32.1826239621
101PhosphorylationEAQVLEKTGRRPSDS
HHHHHHHHCCCCCCC		26.9229899451
106PhosphorylationEKTGRRPSDSVQPAQ
HHHCCCCCCCCCCCC		40.4825521595
108PhosphorylationTGRRPSDSVQPAQHS
HCCCCCCCCCCCCCC		27.3025619855
115PhosphorylationSVQPAQHSPCRGRVC
CCCCCCCCCCCCEEE		17.3925521595
218PhosphorylationKRLATKLSSSLGRSS
HHHHHHHHHHCCCCC		21.3124453211
219PhosphorylationRLATKLSSSLGRSSG
HHHHHHHHHCCCCCC		39.7623737553
220PhosphorylationLATKLSSSLGRSSGK
HHHHHHHHCCCCCCC		31.3127149854
224PhosphorylationLSSSLGRSSGKRVRA
HHHHCCCCCCCCCEE		41.4622324799
225PhosphorylationSSSLGRSSGKRVRAS
HHHCCCCCCCCCEEE		47.1522324799
230MethylationRSSGKRVRASLDSAG
CCCCCCCEEEHHCCC		23.6124129315
230Asymmetric dimethylarginineRSSGKRVRASLDSAG
CCCCCCCEEEHHCCC		23.61-
232PhosphorylationSGKRVRASLDSAGAS
CCCCCEEEHHCCCCC		23.3426239621
235PhosphorylationRVRASLDSAGASGNS
CCEEEHHCCCCCCCC		33.6228066266
239PhosphorylationSLDSAGASGNSPVLL
EHHCCCCCCCCCEEE		37.2728066266
242PhosphorylationSAGASGNSPVLLPTP
CCCCCCCCCEEECCC		21.6528066266
248PhosphorylationNSPVLLPTPAVGGPR
CCCEEECCCCCCCCC		24.6928066266
448PhosphorylationQALAKQGSLYHEMAI
HHHHHCCCCCCEECC		24.2226239621
450PhosphorylationLAKQGSLYHEMAIEP
HHHCCCCCCEECCCC		9.4623984901
465PhosphorylationLDDIAAVTDILAQRE
HHHHHHHHHHHHHCC		16.7626239621
518PhosphorylationLPWGRPRTFSLDAAP
CCCCCCCEEECCCCC		21.9127087446
520PhosphorylationWGRPRTFSLDAAPAD
CCCCCEEECCCCCCC		25.4027087446
529PhosphorylationDAAPADHSLGPSRSV
CCCCCCCCCCCCCCC		35.2525619855
533PhosphorylationADHSLGPSRSVAPLP
CCCCCCCCCCCCCCC		35.0825619855
544PhosphorylationAPLPPQRSPKSRGFY
CCCCCCCCCCCCCCC		31.2826824392
551PhosphorylationSPKSRGFYSKSQLGP
CCCCCCCCCHHHCCH		20.2929514104
562PhosphorylationQLGPWLQSPV-----
HCCHHHCCCC-----		26.0126643407
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RTKN_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RTKN_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RTKN_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RHOA_MOUSERhoaphysical
14966563
RHOA_MOUSERhoaphysical
12015964
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RTKN_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106 AND SER-520, ANDMASS SPECTROMETRY.

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