PK1IP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PK1IP_MOUSE
• UniProt AC: Q9DCE5
• Protein Name: p21-activated protein kinase-interacting protein 1
• Gene Name: Pak1ip1
• Organism: Mus musculus (Mouse).
• Sequence Length: 382
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly..
• Protein Sequence: MELVAGSYEQVLFGFTVQRGPAKSGHQETWTPVADFTHHSHTASLSVLASNSRYVVSGSKDETIHIYDMKRKVEHGALVHHAGTVTCLKFHGNQHLISGAEDGHICIWDVKRWKCLKTFKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLIEGRSAFIKNIKENAHIVEWSPSGGKYIVVVQNKVDVYRLGTASVSGTITNGKRISSVTFLSDSVLAVAGDEEVVRIFDCDSLECLCEFRAHENRVKDMVSFEVPDHHVLVTASNDGFIKMWTLPQDKKVPPSLLCEAKTGARLTCLTVWLDRAANGMASLPPAAEPCPDQPKTIEKESGDTVQEETSEPNSEKSDVSGDSKQPTKGNSPVTAKKRKMATMSEKKRKKKM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
190	Phosphorylation	VQNKVDVYRLGTASV EECCCEEEEECCCEE	8.82	24511133
205	Acetylation	SGTITNGKRISSVTF EEEEECCCEEEEEEE	48.94	8277955
205	Ubiquitination	SGTITNGKRISSVTF EEEEECCCEEEEEEE	48.94	27667366
285	Phosphorylation	QDKKVPPSLLCEAKT CCCCCCHHHHEECCC	28.09	28059163
339	Phosphorylation	GDTVQEETSEPNSEK CCCCCEECCCCCCCC	37.32	25266776
340	Phosphorylation	DTVQEETSEPNSEKS CCCCEECCCCCCCCC	55.10	25266776
344	Phosphorylation	EETSEPNSEKSDVSG EECCCCCCCCCCCCC	58.05	30635358
347	Phosphorylation	SEPNSEKSDVSGDSK CCCCCCCCCCCCCCC	38.91	25619855
350	Phosphorylation	NSEKSDVSGDSKQPT CCCCCCCCCCCCCCC	41.70	25619855
353	Phosphorylation	KSDVSGDSKQPTKGN CCCCCCCCCCCCCCC	36.39	25619855
357	Phosphorylation	SGDSKQPTKGNSPVT CCCCCCCCCCCCCCC	49.44	25619855
361	Phosphorylation	KQPTKGNSPVTAKKR CCCCCCCCCCCHHHH	29.43	27087446
364	Phosphorylation	TKGNSPVTAKKRKMA CCCCCCCCHHHHHHC	35.82	25619855
369	Acetylation	PVTAKKRKMATMSEK CCCHHHHHHCCCCHH	41.59	7969819
376	Acetylation	KMATMSEKKRKKKM- HHCCCCHHHHHHCC-	51.04	71141

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PK1IP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PK1IP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PK1IP_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PK1IP_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.