dbPTM

AVEN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AVEN_MOUSE
UniProt AC	Q9D9K3
Protein Name	Cell death regulator Aven
Gene Name	Aven
Organism	Mus musculus (Mouse).
Sequence Length	342
Subcellular Localization	Endomembrane system Peripheral membrane protein. Associated with intracellular membranes..
Protein Description	Protects against apoptosis mediated by Apaf-1..
Protein Sequence	MQAERGARGGRGRRGGRERPGGDREPVGAATALARGGCGDGGGRRGRGRGFRRGRGGGGLRGGRWEPGGRGGGASTRVEEDSDSETYGEENDEQGNFSRRKIVSNWDRYQDTEKEVNGESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDGETSCPKQNSALYVDSESLVRALEQLPLAVRLNVASELIQTTIPLELPQVKPRRNDDGKELGMHLRGPISELRSAAGACPRSLGRGSLRQSPLEGLQKAPTPTQSVADHLEEELDMLLHLDAPVQEEGNISPDQTSRDQEPEKDGQVAQEETGPEKPSVTREKNVEPEQPSTSKNVTEEELEDWLDSMIS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	REPVGAATALARGGC CCCCCHHHHHHCCCC	22.97	21454597
70	Methylation	GRWEPGGRGGGASTR CCCCCCCCCCCCCCC	46.64	-
82	Phosphorylation	STRVEEDSDSETYGE CCCEECCCCCCCCCC	46.44	25521595
84	Phosphorylation	RVEEDSDSETYGEEN CEECCCCCCCCCCCC	35.47	25521595
86	Phosphorylation	EEDSDSETYGEENDE ECCCCCCCCCCCCCC	40.55	25521595
87	Phosphorylation	EDSDSETYGEENDEQ CCCCCCCCCCCCCCC	20.63	25619855
139	Phosphorylation	LLSSAGDSFSQFRFA EECCCCCCCHHCCCC	26.36	29899451
203	Ubiquitination	PLELPQVKPRRNDDG CCCCCCCCCCCCCCC	27.79	22790023
237	Dimethylation	ACPRSLGRGSLRQSP CCCCHHCCCCCCCCC	36.50	-
243	Phosphorylation	GRGSLRQSPLEGLQK CCCCCCCCCCCHHHC	25.64	28066266
253	Phosphorylation	EGLQKAPTPTQSVAD CHHHCCCCCCHHHHH	43.77	25293948
255	Phosphorylation	LQKAPTPTQSVADHL HHCCCCCCHHHHHHH	35.63	25293948
257	Phosphorylation	KAPTPTQSVADHLEE CCCCCCHHHHHHHHH	23.04	25293948
283	Phosphorylation	VQEEGNISPDQTSRD CCCCCCCCCCCCCCC	26.82	21659605

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AVEN_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AVEN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AVEN_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of AVEN_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AVEN_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND MASSSPECTROMETRY.	15345747 [Abstract]