| UniProt ID | 2ABD_MOUSE | |
|---|---|---|
| UniProt AC | Q925E7 | |
| Protein Name | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform | |
| Gene Name | Ppp2r2d | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 453 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).. | |
| Protein Sequence | MAGAGGGGCPAGGNDFQWCFSQVKGAVDEDVAEADIISTVEFNYSGDLLATGDKGGRVVIFQREQENKGRAHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAHFLLSTNDKTIKLWKISERDKRAEGYNLKDEDGRLRDPFRITALRVPILKPMDLMVEASPRRIFANAHTYHINSISVNSDHETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPHQCNVFVYSSSKGTIRLCDMRSSALCDRHAKFFEEPEDPSSRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLNMEGRPVETHQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSAIMTGSYNNFFRMFDRNTRRDVTLEASRENSKPRASLKPRKVCTGGKRKKDEISVDSLDFNKKILHTAWHPMESIIAVAATNNLYIFQDKIN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 285 | Phosphorylation | PEDPSSRSFFSEIIS CCCCCHHHHHHHHHH | 32.37 | - | |
| 305 | Phosphorylation | KFSHSGRYMMTRDYL EECCCCCEEEECCEE | 8.51 | - | |
| 308 | Phosphorylation | HSGRYMMTRDYLSVK CCCCEEEECCEEEEE | 12.12 | - | |
| 341 | Phosphorylation | YLRSKLCSLYENDCI HHHHHHHHHHCCCCC | 44.41 | 25521595 | |
| 415 | Phosphorylation | KRKKDEISVDSLDFN CCCCCEEEEECCCCC | 20.16 | 22210690 | |
| 418 | Phosphorylation | KDEISVDSLDFNKKI CCEEEEECCCCCHHH | 27.90 | 22210690 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of 2ABD_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of 2ABD_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of 2ABD_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PP2AA_HUMAN | PPP2CA | physical | 26496610 | |
| PP2AB_HUMAN | PPP2CB | physical | 26496610 | |
| 2AAA_HUMAN | PPP2R1A | physical | 26496610 | |
| 2AAB_HUMAN | PPP2R1B | physical | 26496610 | |
| 2ABA_HUMAN | PPP2R2A | physical | 26496610 | |
| KLF4_HUMAN | KLF4 | physical | 26496610 | |
| ADNP2_HUMAN | ADNP2 | physical | 26496610 | |
| GBG12_HUMAN | GNG12 | physical | 26496610 | |
| K2013_HUMAN | KIAA2013 | physical | 26496610 | |
| F122A_HUMAN | FAM122A | physical | 26496610 | |
| C19L2_HUMAN | CWF19L2 | physical | 26496610 | |
| FXL16_HUMAN | FBXL16 | physical | 26496610 | |
| F122B_HUMAN | FAM122B | physical | 26496610 | |
| UNG_HUMAN | UNG | physical | 26496610 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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