WDR61_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR61_MOUSE
• UniProt AC: Q9ERF3
• Protein Name: WD repeat-containing protein 61
• Gene Name: Wdr61
• Organism: Mus musculus (Mouse).
• Sequence Length: 305
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C (By similarity)..
• Protein Sequence: MTNQYSILFKQEQAHDDAIWSVAWETNKKENIETVVTGSLDDLVKVWKWRDERLELQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQMKSIDAGPVDAWTLAFSPDSQYLATGTHMGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCIHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHVYDCPI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTNQYSIL -------CCCCEEEE	7.77	-
2	Acetylation	------MTNQYSILF ------CCCCEEEEE	30.91	-
29	Ubiquitination	VAWETNKKENIETVV EEEECCCCCCEEEEE	59.05	-
97	Ubiquitination	LWDLENGKQMKSIDA EEECCCCEECCCCCC	59.82	-
139	Ubiquitination	IFGVESGKKEYSLDT EEEECCCCEEEEECC	52.27	-
140	Ubiquitination	FGVESGKKEYSLDTR EEECCCCEEEEECCC	66.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR61_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR61_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR61_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCPZ_HUMAN	CCT6A	physical	26496610
NMT1_HUMAN	NMT1	physical	26496610
PFD1_HUMAN	PFDN1	physical	26496610
PFD2_HUMAN	PFDN2	physical	26496610
PP1RA_HUMAN	PPP1R10	physical	26496610
TCPA_HUMAN	TCP1	physical	26496610
TCPG_HUMAN	CCT3	physical	26496610
NCOA4_HUMAN	NCOA4	physical	26496610
TTC37_HUMAN	TTC37	physical	26496610
PFD6_HUMAN	PFDN6	physical	26496610
TCPH_HUMAN	CCT7	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPB_HUMAN	CCT2	physical	26496610
TCPQ_HUMAN	CCT8	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
NIN_HUMAN	NIN	physical	26496610
PAF1_HUMAN	PAF1	physical	26496610
CDC73_HUMAN	CDC73	physical	26496610
TPC13_HUMAN	TRAPPC13	physical	26496610
LEO1_HUMAN	LEO1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.