dbPTM

ING2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ING2_MOUSE
UniProt AC	Q9ESK4
Protein Name	Inhibitor of growth protein 2
Gene Name	Ing2
Organism	Mus musculus (Mouse).
Sequence Length	281
Subcellular Localization	Nucleus. Predominantly cytoplasmic. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm (By similarity)..
Protein Description	Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity)..
Protein Sequence	MLGQQQQQQLYSSAALLTGERSRLLSCYVQDYLECVESLPHDMQRNVSVLRELDNKYQETLKEIDDVYEKYKKEDDSNQKKRLQQHLQRALINSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKSKMDSSQPERSSRRPRRQRTSESRDLCHMTNGIDDCDDQPPKEKRSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDNEKTMDKSTEKTKKERRAR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	QQQQQQLYSSAALLT HHHHHHHHHHHHHHH	9.02	25777480
12	Phosphorylation	QQQQQLYSSAALLTG HHHHHHHHHHHHHHC	23.30	25777480
13	Phosphorylation	QQQQLYSSAALLTGE HHHHHHHHHHHHHCH	12.19	25777480
18	Phosphorylation	YSSAALLTGERSRLL HHHHHHHHCHHHHHH	37.54	25777480
22	Phosphorylation	ALLTGERSRLLSCYV HHHHCHHHHHHHHHH	23.99	25777480
202	Phosphorylation	AKQEREASPVEFAID HHHHHHCCCCCEECC	25.40	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ING2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ING2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ING2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
H33_MOUSE	H3f3a	physical	16728977

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ING2_MOUSE

Related Literatures of Post-Translational Modification